The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.
Likewise, addition of 2-O-desulfated heparin was able to reduce uptake, whereas 6-O-desulfated heparin or chondroitin sulfate (negative control) were significantly less effective at reducing uptake (Fig. 4a) PubMed:29686391
Chondroitin sulfate and 6-O-desulfated heparin incubation did not reduce the median fluorescence, verifying that 6-O-sulfation is also important for tau internalization ex vivo (Fig. 4d and Supplementary Fig. 3b) PubMed:29686391
Treatment of cells with an inhibitor for DNM2, Dynasore, was also able to reduce uptake of tau (Supplementary Fig. 2 f) PubMed:29686391
We found that internalization of tau can be efficiently competed by the presence of heparin or HS in the media (Fig. 4a) PubMed:29686391
Consistent with our previous results, incubation with heparin, heparan sulfate, or 2-O-desulfated heparin reduced uptake of tau as quantified by the median 488 fluorescence intensity (Fig. 4d) PubMed:29686391
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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.