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Corticotropin-releasing factor regulates caspase-3 and may protect developing zebrafish from stress-induced apoptosis 1.0.0

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charles.hoyt@scai.fraunhofer.de at 2019-02-27 16:21:28.818514
Authors
Lingling Xu
Contact
charles.hoyt@scai.fraunhofer.de
License
CC BY 4.0
Copyright
Copyright © 2019 Fraunhofer Institute SCAI, All rights reserved.
Number Nodes
7
Number Edges
14
Number Components
1
Network Density
0.333333333333333
Average Degree
2.0
Number Citations
1
Number BEL Errors
0

Content Statistics

Network Overlap

The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.

Network Overlap
The effect of CRH and its inhibitor, antalarmin, on in vitro growth of preantral mouse follicles, early embryo development, and steroidogenesis. v1.0.0 29%
Molecular Chaperone Functions in Protein Folding and Proteostasis v1.0.0 14%
The CRF1 receptor antagonist, antalarmin, reverses isolation-induced up-regulation of dopamine D2 receptors in the amygdala and nucleus accumbens of fawn-hooded rats v1.0.0 14%
The Ubiquitin Proteasome System in Neurodegenerative Diseases: Sometimes the Chicken, Sometimes the Egg v1.0.0 14%

Sample Edges

a(MESH:antalarmin) decreases bp(MESH:"Heat-Shock Response") View Subject | View Object

However, embryos that recovered from heat shock in the presence of the CRF-R1 antagonist, antalarmin, experienced a greater increase in caspase-3 activity than embryos not given the antagonist PubMed:29807032

Annotations
Experimental Factor Ontology (EFO)
embryonic cell line

a(MESH:antalarmin) increases act(p(NCBIGENE:140621)) View Subject | View Object

However, embryos that recovered from heat shock in the presence of the CRF-R1 antagonist, antalarmin, experienced a greater increase in caspase-3 activity than embryos not given the antagonist PubMed:29807032

Annotations
Experimental Factor Ontology (EFO)
embryonic cell line

a(MESH:antalarmin) causesNoChange a(MESH:"Embryonic Structures") View Subject | View Object

The greatest heat shock-induced mortality occurred during the first 1 h of recovery and plateaued after 5 h recovery (main effect of time P<0.001; n=3; Fig. 3B), but the presence of antalarmin did not influence this response. PubMed:29807032

Annotations
Experimental Factor Ontology (EFO)
embryonic cell line

bp(MESH:"Heat-Shock Response") association act(p(NCBIGENE:140621)) View Subject | View Object

The endogenous response to heat shock was characterized by transient changes in caspase-3 activity and gene expression. PubMed:29807032

bp(MESH:"Heat-Shock Response") increases act(p(NCBIGENE:140621)) View Subject | View Object

For embryos heat shocked at 6 hpf, the induction of caspase-3 activity was dependent on recovery time (interaction of main variables P=0.007), with a significant increase over controls at 7 h and 10 h recovery (Table 1). PubMed:29807032

Sample Nodes

a(MESH:antalarmin)

In-Edges: 0 | Out-Edges: 22 | Explore Neighborhood | Download JSON

bp(MESH:"Heat-Shock Response")

In-Edges: 3 | Out-Edges: 12 | Explore Neighborhood | Download JSON

a(MESH:"Embryonic Structures")

In-Edges: 5 | Out-Edges: 0 | Explore Neighborhood | Download JSON

p(MESH:"corticotropin releasing factor-binding protein")

In-Edges: 2 | Out-Edges: 0 | Explore Neighborhood | Download JSON

p(NCBIGENE:140621)

In-Edges: 4 | Out-Edges: 1 | Explore Neighborhood | Download JSON

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.