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The effect of CRH and its inhibitor, antalarmin, on in vitro growth of preantral mouse follicles, early embryo development, and steroidogenesis. 1.0.0

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charles.hoyt@scai.fraunhofer.de at 2019-02-27 16:21:29.033557
Authors
Lingling Xu
Contact
charles.hoyt@scai.fraunhofer.de
License
CC BY 4.0
Copyright
Copyright © 2018 Fraunhofer Institute SCAI, All rights reserved.
Number Nodes
8
Number Edges
14
Number Components
1
Network Density
0.25
Average Degree
1.75
Number Citations
1
Number BEL Errors
0

Content Statistics

Network Overlap

The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.

Network Overlap
Corticotropin-releasing factor regulates caspase-3 and may protect developing zebrafish from stress-induced apoptosis v1.0.0 29%
Tau Modifications v1.9.5 12%
The CRF1 receptor antagonist, antalarmin, reverses isolation-induced up-regulation of dopamine D2 receptors in the amygdala and nucleus accumbens of fawn-hooded rats v1.0.0 12%

Sample Edges

a(MESH:antalarmin) increases a(MESH:"Embryonic Structures") View Subject | View Object

At all embryo stages, significant differences were noted between the CRH 10􏰁7 and control groups as well as be- tween the CRH 10􏰁7 and CRH 10􏰁7/antalarmin 10􏰁6 groups, with the rates being lower in the former. PubMed:23211705

a(MESH:antalarmin) increases a(MESH:Morula) View Subject | View Object

With regard to the morula/blastocyst stage, the rates in the CRH 10􏰁7 group were lower compared with the control (P 􏰄 0.003) and lower compared with the CRH 10􏰁7/antalarmin 10􏰁6 group (P 􏰃 0.001) (Table 2). PubMed:23211705

a(MESH:antalarmin) increases a(MESH:Blastocyst) View Subject | View Object

With regard to the morula/blastocyst stage, the rates in the CRH 10􏰁7 group were lower compared with the control (P 􏰄 0.003) and lower compared with the CRH 10􏰁7/antalarmin 10􏰁6 group (P 􏰃 0.001) (Table 2). PubMed:23211705

a(MESH:antalarmin) decreases act(p(MGI:Crh)) View Subject | View Object

Interestingly, the addition of a 10-fold excess of the CRH-R1 antagonist, antalarmin, overcame the negative effect of CRH on estradiol release (d 5, P 􏰄 0.009; d 7, P 􏰄 0.010; d 9, P 􏰃 0.001; and d 11, P 􏰄 0.002), indicating that the suppressive effect of CRH was receptor mediated (Fig. 1). PubMed:23211705

a(MESH:antalarmin) decreases act(p(MGI:Crh)) View Subject | View Object

The addition of the CRH-R1 an- tagonist antalarmin in a 10-fold higher concentration compared with that of CRH overcame the effect of CRH on beta􏰇-hCG release (d 11 beta􏰇-hCG 185.6 􏰅 6.087 mIU/ml, P 􏰃 0.001) indicating that the suppressive effect of CRH was recep- tor mediated (Fig. 3). PubMed:23211705

Sample Nodes

a(MESH:antalarmin)

In-Edges: 0 | Out-Edges: 22 | Explore Neighborhood | Download JSON

a(MESH:"Embryonic Structures")

In-Edges: 5 | Out-Edges: 0 | Explore Neighborhood | Download JSON

a(MESH:Blastocyst)

In-Edges: 1 | Out-Edges: 0 | Explore Neighborhood | Download JSON

a(MESH:Estradiol)

In-Edges: 1 | Out-Edges: 0 | Explore Neighborhood | Download JSON

a(MESH:Morula)

In-Edges: 1 | Out-Edges: 0 | Explore Neighborhood | Download JSON

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.