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  3. The CRF1 receptor antagonist, antalarmin, reverses isolation-induced up-regulation of dopamine D2 receptors in the amygdala and nucleus accumbens of fawn-hooded rats v1.0.0

The CRF1 receptor antagonist, antalarmin, reverses isolation-induced up-regulation of dopamine D2 receptors in the amygdala and nucleus accumbens of fawn-hooded rats 1.0.0

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charles.hoyt@scai.fraunhofer.de at 2019-02-27 16:16:03.638462
Authors
Lingling Xu
Contact
charles.hoyt@scai.fraunhofer.de
License
CC BY 4.0
Copyright
Copyright © 2018 Fraunhofer Institute SCAI, All rights reserved.
Number Nodes
15
Number Edges
28
Number Components
1
Network Density
0.133333333333333
Average Degree
1.86666666666667
Number Citations
1
Number BEL Errors
0

Content Statistics

Network Overlap

The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.

Network Overlap
Corticotropin-releasing factor regulates caspase-3 and may protect developing zebrafish from stress-induced apoptosis v1.0.0 14%
The effect of CRH and its inhibitor, antalarmin, on in vitro growth of preantral mouse follicles, early embryo development, and steroidogenesis. v1.0.0 12%

Sample Edges

a(HBP:"SK and F 77434") decreases a(MESH:"8-iodo-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepine-7-ol") View Subject | View Object

Autoradiographic detection of dopamine D1 receptors by [125I]- SCH 23982 was fully displaceable by the agonist SKF-77434. PubMed:16820021

a(MESH:antalarmin) causesNoChange act(p(RGD:Drd1)) View Subject | View Object

Overall, no changes were observed in dopamine D1 receptor binding in the brain regions examined following social isolation and ⁄ or antalarmin treatment under these conditions PubMed:16820021

a(MESH:antalarmin) increases p(RGD:Drd2) View Subject | View Object

antalarmin increased dopamine D2 ⁄ 3 binding in the CPu (+7%, P < 0.001; Fig. 3C) and olfactory tubercle (OT; +15%, P 1⁄4 0.006; Fig. 3D) of group-housed rats. PubMed:16820021

Annotations
MeSH
Neostriatum
MeSH
Olfactory Tubercle

a(MESH:antalarmin) decreases p(RGD:Drd2) View Subject | View Object

Antalar- min treatment reversed this effect and returned dopamine D2 ⁄ 3 receptor density levels back to those of the vehicle-treated GH rats. PubMed:16820021

Annotations
MeSH
Nucleus Accumbens

a(MESH:antalarmin) increases p(RGD:Drd3) View Subject | View Object

antalarmin increased dopamine D2 ⁄ 3 binding in the CPu (+7%, P < 0.001; Fig. 3C) and olfactory tubercle (OT; +15%, P 1⁄4 0.006; Fig. 3D) of group-housed rats. PubMed:16820021

Annotations
MeSH
Neostriatum
MeSH
Olfactory Tubercle

Sample Nodes

a(HBP:"SK and F 77434")

In-Edges: 1 | Out-Edges: 1 | Explore Neighborhood | Download JSON

a(HBP:"[125I]-NCQ")

In-Edges: 1 | Out-Edges: 0 | Explore Neighborhood | Download JSON

a(MESH:"8-iodo-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepine-7-ol")

In-Edges: 2 | Out-Edges: 0 | Explore Neighborhood | Download JSON

a(MESH:antalarmin)

In-Edges: 0 | Out-Edges: 22 | Explore Neighborhood | Download JSON

complex(a(HBP:"SK and F 77434"), p(RGD:Drd1))

In-Edges: 0 | Out-Edges: 2 | Explore Neighborhood | Download JSON

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.