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  3. TFEB enhances astroglial uptake of extracellular tau species and reduces tau spreading v1.0.0

TFEB enhances astroglial uptake of extracellular tau species and reduces tau spreading 1.0.0

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charles.hoyt@scai.fraunhofer.de at 2019-02-27 16:23:09.564541
Authors
Lingling Xu
Contact
charles.hoyt@scai.fraunhofer.de
License
CC BY 4.0
Copyright
Copyright © 2018 Fraunhofer Institute SCAI, All rights reserved.
Number Nodes
26
Number Edges
36
Number Components
1
Network Density
0.0553846153846154
Average Degree
1.38461538461538
Number Citations
1
Number BEL Errors
0

Content Statistics

Network Overlap

The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.

Network Overlap
Tau clearance mechanisms and their possible role in the pathogenesis of Alzheimer disease v1.0.0 35%
Tau protein aggregation is associated with cellular senescence in the brain v1.0.0 19%
Tau Modifications v1.9.5 15%
Tau in physiology and pathology v1.0.0 12%
Tau oligomers-Cytotoxicity, propagation, and mitochondrial damage v1.0.0 12%
Imbalances in the Hsp90 Chaperone Machinery: Implications for Tauopathies v1.0.0 12%
Clearance of Amyloid Beta and Tau in Alzheimer’s Disease:from Mechanisms to Therapy v1.0.1 12%
TAU and Interaction Partners v1.2.5 12%
Alzheimer’s disease and the autophagic-lysosomal system v1.0.0 12%
mTOR-Related Brain Dysfunctions in Neuropsychiatric Disorders v1.0.0 12%

Sample Edges

p(MGI:Mapt) hasVariant p(MGI:Mapt, pmod(Ph)) View Subject | View Object

a(MESH:Astrocytes) increases p(MGI:Tfeb) View Subject | View Object

Transcriptomic analysis of these isolated astrocytes revealed an increase in TFEB tran- scripts, as well as transcripts of several of its well-known target genes in the rTg4510 relative to wild-type controls PubMed:30108137

act(a(MESH:Astrocytes)) increases a(HBP:"Tau fibrils") View Subject | View Object

In addition, flow cytometry analysis demonstrated that heparin reduces dye-conjugated pff uptake in both TFEB and EGFP transduced astrocytes, suggesting that macropino- cytosis is responsible for astroglial pff uptake PubMed:30108137

Annotations
Cell Ontology (CL)
astrocyte

bp(MESH:Pinocytosis) increases act(a(MESH:Astrocytes)) View Subject | View Object

In addition, flow cytometry analysis demonstrated that heparin reduces dye-conjugated pff uptake in both TFEB and EGFP transduced astrocytes, suggesting that macropino- cytosis is responsible for astroglial pff uptake PubMed:30108137

Annotations
Cell Ontology (CL)
astrocyte

p(FPLX:mTORC1) increases p(MGI:Tfeb, pmod(Ph)) View Subject | View Object

Inhibiting mTORC1 blocks the phosphor- ylation of TFEB, allowing unphosphorylated TFEB to translocate to the nucleus and become transcriptionally active PubMed:30108137

Annotations
Cell Ontology (CL)
astrocyte

Sample Nodes

p(HGNC:CTSD)

In-Edges: 6 | Out-Edges: 12 | Explore Neighborhood | Download JSON

path(MESH:"Cognitive Dysfunction")

In-Edges: 27 | Out-Edges: 20 | Explore Neighborhood | Download JSON

path(MESH:Gliosis)

In-Edges: 6 | Out-Edges: 0 | Explore Neighborhood | Download JSON

a(MESH:Astrocytes)

In-Edges: 3 | Out-Edges: 11 | Explore Neighborhood | Download JSON

a(MESH:Lysosomes)

In-Edges: 4 | Out-Edges: 4 | Explore Neighborhood | Download JSON

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.