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Tau protein aggregation is associated with cellular senescence in the brain 1.0.0

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charles.hoyt@scai.fraunhofer.de at 2019-02-27 16:23:12.660246
Authors
Sandra Spalek
Contact
charles.hoyt@scai.fraunhofer.de
License
CC BY 4.0
Copyright
Copyright © 2018 Fraunhofer Institute SCAI, All rights reserved
Number Nodes
77
Number Edges
152
Number Components
2
Network Density
0.025974025974026
Average Degree
1.97402597402597
Number Citations
1
Number BEL Errors
0

Content Statistics

Network Overlap

The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.

Network Overlap
Estrogen receptor-α is localized to neurofibrillary tangles in Alzheimer's disease v1.0.0 33%
Inert and seed-competent tau monomers suggest structural origins of aggregation v1.0.0 25%
Anti-inflammatory activity of anatabine via inhibition of STAT3 phosphorylation v1.0.0 24%
Heme Curation v0.0.1-dev 22%
Inflammasome Involvement in Alzheimer’s Disease v1.0.0 22%
Chronic Anatabine Treatment Reduces Alzheimer ’ s Disease (AD)-Like Pathology and Improves Socio-Behavioral Deficits in a Transgenic Mouse Model of AD v1.0.0 20%
Increased NF-κB signalling up-regulates BACE1 expression and its therapeutic potential in Alzheimer's disease. v1.0.0 20%
In Vivo and In Vitro Characterization of Antalarmin, a Nonpeptide Corticotropin-Releasing Hormone (CRH) Receptor Antagonist: Suppression of Pituitary ACTH Release and Peripheral Inflammation v1.0.0 20%
TFEB enhances astroglial uptake of extracellular tau species and reduces tau spreading v1.0.0 19%
A role for b2* nicotinic receptors in a model of local amyloid pathology induced in dentate gyrus v1.0.0 19%

Sample Edges

p(MGI:Mapt) hasVariant p(MGI:Mapt, var("p.Pro301Leu")) View Subject | View Object

p(MGI:Mapt) hasVariant p(MGI:Mapt, pmod(Ph)) View Subject | View Object

a(CHEBI:"amyloid-beta") causesNoChange p(MGI:Cdkn2a) View Subject | View Object

In 15-month-old mice with heavy Abeta deposition and phosphorylated tau, but lacking NFT pathology (Orr et al., 2014), Cdkn2a expression was not elevated (Figure 4e). These data indicate that Cdkn2a expression was neither a response to general protein accumulation, nor to pre-NFT tau pathology, but instead required the presence of NFTs PubMed:30126037

Annotations
Confidence
High
MeSH
Cerebral Cortex
MeSH
Hippocampus
MeSH
Alzheimer Disease

a(GO:"neurofibrillary tangle") decreases bp(GO:cognition) View Subject | View Object

Tau-containing neurofibrillary tangle (NFT) accumulation is the closest correlate with cognitive decline and cell loss (Arriagada et al., 1992), yet mechanisms mediating tau toxicity are poorly understood PubMed:30126037

Annotations
Confidence
High

a(GO:"neurofibrillary tangle") increases bp(GO:"cell death") View Subject | View Object

Tau-containing neurofibrillary tangle (NFT) accumulation is the closest correlate with cognitive decline and cell loss (Arriagada et al., 1992), yet mechanisms mediating tau toxicity are poorly understood PubMed:30126037

Annotations
Confidence
High

Sample Nodes

a(CHEBI:"amyloid-beta")

In-Edges: 423 | Out-Edges: 245 | Children: 5 | Explore Neighborhood | Download JSON

bp(GO:"cellular respiration")

In-Edges: 6 | Out-Edges: 3 | Explore Neighborhood | Download JSON

bp(GO:"inflammatory response")

In-Edges: 55 | Out-Edges: 24 | Explore Neighborhood | Download JSON

bp(GO:cognition)

In-Edges: 111 | Out-Edges: 35 | Explore Neighborhood | Download JSON

bp(MESH:"Cerebrovascular Circulation")

In-Edges: 10 | Out-Edges: 7 | Explore Neighborhood | Download JSON

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.