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  3. TFEB enhances astroglial uptake of extracellular tau species and reduces tau spreading v1.0.0
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Biogrammar Summary of TFEB enhances astroglial uptake of extracellular tau species and reduces tau spreading 1.0.0

Table of Contents

  1. Regulatory Pairs
  2. Contradictory Pairs
  3. Causal Pathologies

Regulatory Pairs 1

These pairs of nodes represent motifs like A increases B and B decreases A.

Node A Node B
path(MESH:Tauopathies) p(MGI:Tfeb)

Contradictory Statements 1

These pairs of nodes have a contradiction in their causal relationships, meaning they have more than one of INCREASES, DECREASES, or CAUSES NO CHANGE. This may be due to different experimental conditions, so these statements need to be carefully considered in analyses.

Source Relations Target
p(MGI:Tfeb) decreases, causesNoChange p(MGI:Mapt, pmod(Ph))

Causal Pathologies 7

Pathologies are more dogmatically the result of molecular and physical processes, and do not necessarily make sense as the subject of causal statements.

Source Relation Target
path(MESH:"Frontotemporal Dementia") increases p(HGNC:CTSD)
path(MESH:"Frontotemporal Dementia") increases p(HGNC:TFEB)
path(MESH:"Frontotemporal Dementia") increases r(HGNC:LAMP1)
path(MESH:"Frontotemporal Dementia") increases r(HGNC:TFEB)
path(MESH:Tauopathies) increases p(MGI:Ctsd)
path(MESH:Tauopathies) increases p(MGI:Lamp1)
path(MESH:Tauopathies) increases p(MGI:Tfeb)

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.