a(MESH:Lysosomes)
This demonstrates that in the absence of mutant PS1, AD-associated impairment in autophagy occurs and thus is due to other factors. Treatment of ex vivo hippocampal slice cultures with lysosomal disruptors causes the formation of enlarged, dystrophic neurites filled with AVs and lysosomes, similar to what is seen in mouse AD models and human AD tissue (85, 86) PubMed:24027553
TFEB activation has been linked to lysosomal stress and the ac- cumulation of aberrant protein aggregates, indicated by TFEB’s nuclear localization in lysosomal storage disorders PubMed:30108137
In sum, these results demonstrate that TFEB regulates the lysosomal pathway in primary astrocytes. PubMed:30108137
. Proteins can be degraded either individually or en masse by proteasomes (20) or lysosomes (21), respectively. PubMed:25784053
Alternatively, bulkier substrates, such as large inclusions, can be directed to the lysosome, a membrane-bound organelle containing a host of nonspecific proteases that can degrade a wide range of substrates (21). PubMed:25784053
This demonstrates that in the absence of mutant PS1, AD-associated impairment in autophagy occurs and thus is due to other factors. Treatment of ex vivo hippocampal slice cultures with lysosomal disruptors causes the formation of enlarged, dystrophic neurites filled with AVs and lysosomes, similar to what is seen in mouse AD models and human AD tissue (85, 86) PubMed:24027553
starvation or lysosomal dysfunction increases tau release PubMed:29238289
BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.
If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.