The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.
Rab7a (Rodriguez et al., 2017) and Rab1a (Mohamed et al., 2017) have been recently implicated in tau release, further suggesting that tau release involves vesicle transport. PubMed:29238289
Tau from the CSF (Saman et al., 2012) and blood of patients with AD (Fiandaca et al., 2015) is associated with exosomes PubMed:29238289
starvation or lysosomal dysfunction increases tau release PubMed:29238289
N2a cells over-expressing tau (Wang et al., 2017) and microglia also release tau in an exosome-dependent manner PubMed:29238289
Tau is well-recognized for its role in assembling/stabilizing microtubules although tau single knockout mice do not show major phenotypic changes in neuronal microtubule stability because of a putative functional redundancy PubMed:29238289
BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.
If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.