bp(MESH:Proteolysis)
. Proteins can be degraded either individually or en masse by proteasomes (20) or lysosomes (21), respectively. PubMed:25784053
Proteome fidelity is maintained by the protein homeostasis (proteostasis) network (PN), a multi-compartmental system that coordinatesprotein synthesis, folding, disaggregation, and degradation (1). PubMed:25784053
As such, HSP70 and HSP90 are central to the process of triaging proteins for refolding or elimination. PubMed:25784053
As such, HSP70 and HSP90 are central to the process of triaging proteins for refolding or elimination. PubMed:25784053
. Proteins can be degraded either individually or en masse by proteasomes (20) or lysosomes (21), respectively. PubMed:25784053
All three proteolytic activities have been reported to be decreased in AD brains (Keller et al., 2000). PubMed:23528736
Flow cytometry analysis of primary astrocytes incubated with DQ-BSA revealed an ∼60% increase in median fluorescence for TFEB-transduced astro- cytes, indicating that TFEB enhances uptake and proteolysis of DQ-BSA PubMed:30108137
All of these chaperones assist in various ways to help fold, refold and degrade misfolded proteins. PubMed:29311797
Not only does aging lead to an increased likelihood of protein misfolding and aggregation, it is compounded by a decrease in the efficiency of the protein degradation machinery. PubMed:29311797
Hsp90 requires ATP to perform these functions including protein degradation, protein folding, prevention of protein aggregation, and protein modification (Echeverría et al., 2011). PubMed:29311797
Proteome fidelity is maintained by the protein homeostasis (proteostasis) network (PN), a multi-compartmental system that coordinatesprotein synthesis, folding, disaggregation, and degradation (1). PubMed:25784053
All of these chaperones assist in various ways to help fold, refold and degrade misfolded proteins. PubMed:29311797
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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.