a(MESH:"Molecular Chaperones")
The UPR is a mechanism that involves a stress response in the ER, including increased biosynthesis of ER chaperones, in response to accumulation of misfolded/denatured/mutated proteins in this organelle (for a recent review on UPR, see Kaufman, 2002). PubMed:14556719
Upon increased levels of nonnative proteins, HSF1 is released from its repressive complex, acquires DNA-binding activity through homotrimerization, and rapidly translocates to the nucleus to induce expression of genes encoding molecular chaperones (7, 35). PubMed:25784053
Molecular chaperones are abundant and highly conserved proteins that assume an important role in protein quality control PubMed:21882945
All of these chaperones assist in various ways to help fold, refold and degrade misfolded proteins. PubMed:29311797
All of these chaperones assist in various ways to help fold, refold and degrade misfolded proteins. PubMed:29311797
For exam- ple, small molecules (e.g., geldanamycin) that activate heat shock factor 1, the main transcrip- tional regulator of the cytosolic stress response, increase the effective concentration of cytosolic chaperones and suppress the aggregation of various disease proteins (8, 38, 228–230). PubMed:23746257
As discussed above, one approach is to employ specialized molecular chaperone machines to release misfolded proteins from aggregates and direct them to the proteasome for degradation (19). PubMed:25784053
Molecular chaperones are abundant and highly conserved proteins that assume an important role in protein quality control PubMed:21882945
All of these chaperones assist in various ways to help fold, refold and degrade misfolded proteins. PubMed:29311797
All of these chaperones assist in various ways to help fold, refold and degrade misfolded proteins. PubMed:29311797
Genetic approaches using these disease models demonstrate that the chaperome plays a crucial role in protecting cells from proteotoxicity. PubMed:27491084
A key role of molecular chaperones is preventing pro- tein aggregation, especially under conditions of cellular stress. PubMed:23746257
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