Upload at 2019-02-27 16:23:07.586063
Rana Aldisi
CC BY 4.0
Copyright © 2018 Fraunhofer Institute SCAI, All rights reserved.
Number Nodes
Number Edges
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Average Degree
Number Citations
Number BEL Errors

Content Statistics

Network Overlap

The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.

Network Overlap
Tau Modifications v1.9.5 38%
Tau in physiology and pathology v1.0.0 29%
TAU and Interaction Partners v1.2.5 29%
Extracellular low-n oligomers of tau cause selective synaptotoxicity without affecting cell viability v1.0.0 21%
Nicotinic acetylcholine receptor signalling: roles in Alzheimer's disease and amyloid neuroprotection. v1.0.0 21%
Tau Antibody Targeting Pathological Species Blocks Neuronal Uptake and Interneuron Propagation of Tau in Vitro v1.0.0 18%
Posiphen as a candidate drug to lower CSF amyloid precursor protein, amyloid-b peptide and s levels: target engagement, tolerability and pharmacokinetics in humans v0.1.0 18%
Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer’s disease brain v1.0.1 18%
Alzheimer's disease-type neuronal tau hyperphosphorylation induced by A beta oligomers v1.0.0 17%
Neuropathogenic role of adenylate kinase-1 in Aβ-mediated tau phosphorylation via AMPK and GSK3β. v1.0.0 17%

Sample Edges

a(CHEBI:"latrunculin A") increases bp(GO:"actin filament depolymerization") View Subject | View Object

For this, we treated our primary cortical neurons with jasplakinolide (1 M), a compound that promotes actin polymerization (Lazaro- Dieguez et al., 2008), or with a latrunculin A (at 500 nM), a compound that depolymerizes F-actin into soluble globular actin (Gactin; Coue´ et al., 1987; Fig. 5C). After jasplakinolide application, we observed a large increase in synaptic EGFP-tau fluorescence PubMed:24760868

Text Location

a(CHEBI:"latrunculin A") increases bp(GO:"actin filament depolymerization") View Subject | View Object

Latrunculin treatment produced rapid actin depolymerization and the corresponding disappearance of LifeAct-RFP fluorescence in every spine studied; no synaptic EGFP-tau fluorescence was observed (data not shown). PubMed:24760868

Text Location

Sample Nodes


In-Edges: 477 | Out-Edges: 480 | Classes: 11 | Children: 27 | Explore Neighborhood | Download JSON

p(HGNC:MAPT, pmod(Ph))

In-Edges: 201 | Out-Edges: 71 | Classes: 1 | Children: 4 | Explore Neighborhood | Download JSON


In-Edges: 6 | Out-Edges: 2 | Explore Neighborhood | Download JSON


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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.