The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.
Using a similar mouse model, Shi et al. treated animals with the antimalarial drug artemisinin, showing that this treatment results in inhibition of NFkB and presumably the NLRP3 inflammasome (13) PubMed:28019679
Using a similar mouse model, Shi et al. treated animals with the antimalarial drug artemisinin, showing that this treatment results in inhibition of NFkB and presumably the NLRP3 inflammasome (13) PubMed:28019679
One of the canonical pathways of this innate immune response evoked by Abeta is the activation of the NOD-like receptor (NLR) family, pyrin domain containing 3 (NLRP3) inflammasome that became a focus of intense research PubMed:28019679
NLRP3 inflammasome activation results from TLR ligation and concomitant uptake of Ab in models of AD PubMed:28019679
NLRP3 inflammasome formation and subsequent activation of caspase-1 cleavage capacity was instrumental for Abeta-induced nitric oxide production and TNF-a release PubMed:28019679
BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.
If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.