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Amyloidogenic subgraph

Name
Amyloidogenic subgraph
Namespace Keyword
Subgraph
Namespace
NeuroMMSigDB
Namespace Version
1.0.3
Namespace URL
https://arty.scai.fraunhofer.de/artifactory/bel/annotation/neurommsig/neurommsig-1.0.3.belanno

Sample Annotated Edges 5

a(CHEBI:"amyloid-beta") increases bp(GO:"innate immune response") View Subject | View Object

One of the canonical pathways of this innate immune response evoked by Abeta is the activation of the NOD-like receptor (NLR) family, pyrin domain containing 3 (NLRP3) inflammasome that became a focus of intense research PubMed:28019679

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Amyloidogenic subgraph
NeuroMMSigDB
Innate immune system subgraph

a(CHEBI:"amyloid-beta") increases act(complex(GO:"NLRP3 inflammasome complex")) View Subject | View Object

NLRP3 inflammasome activation results from TLR ligation and concomitant uptake of Ab in models of AD PubMed:28019679

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Amyloidogenic subgraph

a(CHEBI:"amyloid-beta") increases a(CHEBI:"nitric oxide") View Subject | View Object

NLRP3 inflammasome formation and subsequent activation of caspase-1 cleavage capacity was instrumental for Abeta-induced nitric oxide production and TNF-a release PubMed:28019679

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Amyloidogenic subgraph
NeuroMMSigDB
Nitric oxide subgraph

a(CHEBI:"amyloid-beta") increases sec(p(HGNC:TNF)) View Subject | View Object

NLRP3 inflammasome formation and subsequent activation of caspase-1 cleavage capacity was instrumental for Abeta-induced nitric oxide production and TNF-a release PubMed:28019679

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Amyloidogenic subgraph
NeuroMMSigDB
Tumor necrosis factor subgraph

a(CHEBI:"amyloid-beta") increases act(complex(GO:"NLRP1 inflammasome complex")) View Subject | View Object

Further data, showing “neuronal pyroptosis” of Abeta exposed neurons in a NLRP1- dependent and caspase-1-mediated manner may point to a vicious cycle, by which NLRP1 is causing neurodegeneration in response to increased Abeta production (14) PubMed:28019679

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons
NeuroMMSigDB
Amyloidogenic subgraph

Showing 5 of 45 edges

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.