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Anatabine ameliorates experimental autoimmune thyroiditis. 1.0.0

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charles.hoyt@scai.fraunhofer.de at 2019-03-15 15:36:29.936787
Authors
Esther Wollert
Contact
charles.hoyt@scai.fraunhofer.de
License
CC BY 4.0
Copyright
Copyright © 2019 Fraunhofer Institute SCAI, All rights reserved.
Number Nodes
15
Number Edges
18
Number Components
2
Network Density
0.0857142857142857
Average Degree
1.2
Number Citations
1
Number BEL Errors
0

Content Statistics

Network Overlap

The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.

Network Overlap
Phytochemicals as inhibitors of NF-κB for treatment of Alzheimer’s disease v1.0.0 33%
Upstream regulators and downstream effectors of NF-κBinAlzheimer's disease v1.0.0 27%
Anti-inflammatory activity of anatabine via inhibition of STAT3 phosphorylation v1.0.0 27%
Chronic Anatabine Treatment Reduces Alzheimer ’ s Disease (AD)-Like Pathology and Improves Socio-Behavioral Deficits in a Transgenic Mouse Model of AD v1.0.0 20%
albuquerque2009 v1.0.0 20%
In Vivo and In Vitro Characterization of Antalarmin, a Nonpeptide Corticotropin-Releasing Hormone (CRH) Receptor Antagonist: Suppression of Pituitary ACTH Release and Peripheral Inflammation v1.0.0 20%
Activation and regulation of the inflammasomes v1.0.0 20%
Discriminative Stimulus Properties of S(−)-Nicotine: “A Drug for All Seasons v1.0.0 13%
Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis v1.0.0 13%
Heme Curation v0.0.1-dev 13%

Sample Edges

a(CHEBI:Anatabine) decreases act(p(FPLX:NFkappaB)) View Subject | View Object

Furthermore, anatabine has been recently shown to inhibit nuclear factor-kB(NF-kB) activation and reduce neuroinflammation in a mouse model of Alzheimer disease (15). PubMed:22807490

Annotations
MeSH
Alzheimer Disease

a(CHEBI:Anatabine) decreases bp(GO:"inflammatory response") View Subject | View Object

Furthermore, anatabine has been recently shown to inhibit nuclear factor-kB(NF-kB) activation and reduce neuroinflammation in a mouse model of Alzheimer disease (15). PubMed:22807490

Annotations
MeSH
Neurons
MeSH
Alzheimer Disease

a(CHEBI:Anatabine) decreases path(MESH:"Thyroiditis, Autoimmune") View Subject | View Object

Anatabine significantly decreased the severity of EAT induced with our standard induction protocol. PubMed:22807490

a(CHEBI:Anatabine) decreases a(MESH:Thyroglobulin) View Subject | View Object

Anatabine treated mice developed lower levels of thyroglobulin antibodies than controls on d 14 (P  0.029) and d 21 (P  0.045) (Fig. 2A), suggesting that anatabine atten- uates the thyroid-specific autoimmune response in- duced by thyroglobulin immunization. PubMed:22807490

Annotations
MeSH
Thyroiditis, Autoimmune

a(CHEBI:Anatabine) decreases p(HGNC:IL1R2) View Subject | View Object

Anatabine suppressed the EAT-mediated increase of IL-1 receptor type 2 (IL-1R2, Figure 3A) and IL-18 (Fig. 3B), restoring their expression to levels similar to those seen in normal unimmunized thyroids. PubMed:22807490

Sample Nodes

bp(GO:"inflammatory response")

In-Edges: 55 | Out-Edges: 24 | Explore Neighborhood | Download JSON

path(MESH:Smoking)

In-Edges: 4 | Out-Edges: 6 | Explore Neighborhood | Download JSON

p(HGNC:PTGS2)

In-Edges: 20 | Out-Edges: 7 | Explore Neighborhood | Download JSON

path(MESH:"Colitis, Ulcerative")

In-Edges: 3 | Out-Edges: 1 | Explore Neighborhood | Download JSON

p(FPLX:NFkappaB)

In-Edges: 82 | Out-Edges: 37 | Explore Neighborhood | Download JSON

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.