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Carboxy terminus heat shock protein 70 interacting protein reduces tau-associated degenerative changes 1.0.0

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Provenance

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charles.hoyt@scai.fraunhofer.de at 2019-03-15 15:44:12.845631
Authors
Sandra Spalek
Contact
charles.hoyt@scai.fraunhofer.de
License
CC BY 4.0
Copyright
Copyright © 2019 Fraunhofer Institute SCAI, All rights reserved.
Number Nodes
48
Number Edges
127
Number Components
1
Network Density
0.0562943262411347
Average Degree
2.64583333333333
Number Citations
1
Number BEL Errors
0

Content Statistics

Network Overlap

The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.

Network Overlap
Estrogen receptor-α is localized to neurofibrillary tangles in Alzheimer's disease v1.0.0 50%
Inert and seed-competent tau monomers suggest structural origins of aggregation v1.0.0 38%
Tau in physiology and pathology v1.0.0 33%
Alzheimer’s disease and the autophagic-lysosomal system v1.0.0 33%
Tau Modifications v1.9.5 31%
The Ubiquitin–Proteasome System and the Autophagic–Lysosomal System in Alzheimer Disease v1.0.0 31%
Alzheimer's disease pathological lesions activate the spleen tyrosine kinase. v1.0.0 29%
Tau Trimers Are the Minimal Propagation Unit Spontaneously Internalized to Seed Intracellular Aggregation v1.0.0 27%
Molecular chaperones and regulation of tau quality control: strategies for drug discovery in tauopathies v1.0.0 27%
Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer’s disease brain v1.0.1 24%

Sample Edges

p(HGNC:MAPT) hasVariant p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) View Subject | View Object

complex(p(FPLX:HSP90), p(HGNC:STUB1)) hasComponent p(FPLX:HSP90) View Subject | View Object

complex(p(FPLX:HSP90), p(HGNC:STUB1)) hasComponent p(HGNC:STUB1) View Subject | View Object

p(HGNC:MAPT) hasVariant p(HGNC:MAPT, pmod(Ph, Ser, 262)) View Subject | View Object

p(HGNC:MAPT) hasVariant p(HGNC:MAPT, pmod(Ub)) View Subject | View Object

Sample Nodes

path(MESH:"Alzheimer Disease")

In-Edges: 536 | Out-Edges: 704 | Classes: 5 | Explore Neighborhood | Download JSON

p(HGNC:MAPT)

In-Edges: 477 | Out-Edges: 480 | Classes: 11 | Children: 27 | Explore Neighborhood | Download JSON

p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))

In-Edges: 66 | Out-Edges: 47 | Explore Neighborhood | Download JSON

a(GO:"neurofibrillary tangle")

In-Edges: 74 | Out-Edges: 61 | Children: 1 | Explore Neighborhood | Download JSON

bp(GO:"cell death")

In-Edges: 44 | Out-Edges: 5 | Explore Neighborhood | Download JSON

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.