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Biogrammar Summary of Pathological missorting of endogenous MAPT/Tau in neurons caused by failure of protein degradation systems 1.0.1

Versions 2

Table of Contents

  1. Contradictory Pairs
  2. Contradictory Triplets

Contradictory Statements 2

These pairs of nodes have a contradiction in their causal relationships, meaning they have more than one of INCREASES, DECREASES, or CAUSES NO CHANGE. This may be due to different experimental conditions, so these statements need to be carefully considered in analyses.

Source Relations Target
bp(GO:aging) decreases, increases p(HGNC:MAPT)
p(FPLX:Proteasome) decreases, increases p(HGNC:MAPT)

Contradictory Triplets 2

Analysis of triple stability comes from a deep graph theoretic background. It identifies triangles within the graph that have logically inconsistent relations.

Separately Unstable Triplet
When both A positiveCorrelation B, B negativeCorrelation C, but C positiveCorrelation A.
Mutually Unstable Triplets
When both A negativeCorrelation B, B negativeCorrelation C, and C negativeCorrelation A.
Jens Contradictory Triplet
When A increases B, A decreases C, and C positiveCorrelation A.
Increase Mismatch Triplet
When A increases B, A increases C, and C negativeCorrelation A.
Decrease Mismatch Triplet
When A decreases B, A decreases C, and C negativeCorrelation A.
Type Node A Node B Node C
Jens a(CHEBI:wortmannin) bp(GO:autophagy) p(HGNC:MAPT)
Jens a(CHEBI:rolipram) p(FPLX:Proteasome) p(HGNC:MAPT)

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.