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Neural Systems Governed by Nicotinic Acetylcholine Receptors: Emerging Hypotheses 1.0.0

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charles.hoyt@scai.fraunhofer.de at 2019-02-27 16:16:50.325026
Authors
Sandra Spalek
Contact
charles.hoyt@scai.fraunhofer.de
License
CC BY 4.0
Copyright
Copyright © 2018 Fraunhofer Institute SCAI, All rights reserved.
Number Nodes
106
Number Edges
237
Number Components
3
Network Density
0.0212938005390836
Average Degree
2.23584905660377
Number Citations
1
Number BEL Errors
0

Content Statistics

Network Overlap

The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.

Network Overlap
Nicotinic Receptor Abnormalities of Alzheimer’s Disease: Therapeutic Implications v1.0.0 37%
Neuronal Nicotinic Acetylcholine Receptor Structure and Function and Response to Nicotine v1.0.1 35%
Naturally-expressed nicotinic acetylcholine receptor subtypes v1.0.0 29%
Nicotinic Acetylcholine Receptors and Nicotinic Cholinergic Mechanisms of the Central Nervous System v1.0.0 28%
Alzheimer's Disease: Targeting the Cholinergic System v1.0.0 27%
albuquerque2009 v1.0.0 26%
NACHO Mediates Nicotinic Acetylcholine Receptor Function throughout the Brain v1.0.0 26%
Up-regulation of Nicotinic Receptors by Nicotine Varies with Receptor Subtype v1.0.0 25%
Structural and functional properties of prefibrillar α-synuclein oligomers v1.0.0 23%
Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system v1.0.0 23%

Sample Edges

p(HGNC:CHRNA7) hasVariant p(HGNC:CHRNA7, var("?")) View Subject | View Object

a(CHEBI:"gamma-aminobutyric acid") increases act(p(HGNC:GABBR1)) View Subject | View Object

The neurons release additional GABA, activating presynaptic GABAB receptors on the excitatory inputs to pyramidal neurons, which diminish the release of glutamate onto the pyramidal neurons (Figure 2) PubMed:21482353

Annotations
MeSH
Pyramidal Cells

a(CHEBI:"gamma-aminobutyric acid") increases act(p(HGNC:GABBR2)) View Subject | View Object

The neurons release additional GABA, activating presynaptic GABAB receptors on the excitatory inputs to pyramidal neurons, which diminish the release of glutamate onto the pyramidal neurons (Figure 2) PubMed:21482353

Annotations
MeSH
Pyramidal Cells

a(CHEBI:"gamma-aminobutyric acid") decreases tloc(a(CHEBI:"glutamate(2-)"), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) View Subject | View Object

The neurons release additional GABA, activating presynaptic GABAB receptors on the excitatory inputs to pyramidal neurons, which diminish the release of glutamate onto the pyramidal neurons (Figure 2) PubMed:21482353

Annotations
MeSH
Pyramidal Cells

a(CHEBI:acetylcholine) increases act(p(FPLX:CHRM)) View Subject | View Object

We now realize that acetylcholine liberated from cholinergic nerve terminals often activates both nAChRs and muscarinic receptors PubMed:21482353

Sample Nodes

bp(GO:cognition)

In-Edges: 111 | Out-Edges: 35 | Explore Neighborhood | Download JSON

bp(GO:learning)

In-Edges: 52 | Out-Edges: 24 | Explore Neighborhood | Download JSON

bp(GO:memory)

In-Edges: 112 | Out-Edges: 33 | Explore Neighborhood | Download JSON

path(MESH:"Parkinson Disease")

In-Edges: 68 | Out-Edges: 53 | Explore Neighborhood | Download JSON

a(CHEBI:"calcium(2+)")

In-Edges: 56 | Out-Edges: 30 | Explore Neighborhood | Download JSON

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.