The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.
In terms of functional effects, nicotine acts acutely much in the way that ACh does, causing opening of nAChR channels. PubMed:21787755
There is an emerging consensus that nAChR a6 subunit mRNA and proteins are distributed in brain regions thought to be involved in reward and drug reinforcement, in theory being involved in DA release [135]. PubMed:21787755
There is an emerging consensus that nAChR a6 subunit mRNA and proteins are distributed in brain regions thought to be involved in reward and drug reinforcement, in theory being involved in DA release [135]. PubMed:21787755
In terms of functional effects, nicotine acts acutely much in the way that ACh does, causing opening of nAChR channels. PubMed:21787755
Also, Endo et al. [141] found naturally-expressed a3b2- and a6b2-nAChRs on superior colli- culus neurons, and these receptors are likely located on pre- synaptic terminals of GABAergic neurons where they modulate GABA release. PubMed:21787755
BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.
If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.