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Appears in Networks 4

In-Edges 11

a(CHEBI:"amyloid-beta") decreases act(p(FPLX:CHRM)) View Subject | View Object

Although Aβ peptides negatively alter the cholinergic system at multiple sites, including ACh synthesis, ACh release, and muscarinic receptors (157), the discovery that Aβ1−42 binds to α7 nAChRs with high affinity suggested the potential for a causal role of nAChRs in AD (159, 160). PubMed:17009926

a(CHEBI:acetylcholine) increases act(p(FPLX:CHRM)) View Subject | View Object

When cholinergic neurons are depolarized, ACh is exocytosed from synaptic vesicles and released into the synaptic cleft, where it can activate both muscarinic and nicotinic receptors PubMed:26813123

a(CHEBI:atropine) decreases act(p(FPLX:CHRM)) View Subject | View Object

The two best known muscarinic receptor antagonists are atropine and quinuclidinyl benzilate, which block all muscarinic receptors PubMed:26813123

a(MESH:"Quinuclidinyl Benzilate") decreases act(p(FPLX:CHRM)) View Subject | View Object

The two best known muscarinic receptor antagonists are atropine and quinuclidinyl benzilate, which block all muscarinic receptors PubMed:26813123

complex(a(CHEBI:Muscarine), p(FPLX:CHRM)) increases act(p(FPLX:CHRM)) View Subject | View Object

The first selective agonist identified for muscarinic receptors was muscarine and, so far, there is no agonist available with a specific selectivity for one particular subtype of muscarinic receptor PubMed:26813123

p(MGI:App, var("?")) decreases p(FPLX:CHRM) View Subject | View Object

In addition, quantitative autoradiography assay revealed that choline uptake was reduced in the hippocampus of these animals and that the expression of muscarinic and nicotinic cholinergic receptors was diminished PubMed:26813123

path(MESH:"Alzheimer Disease") decreases p(FPLX:CHRM) View Subject | View Object

Binding studies performed with the use of [3H]-nicotine and [3H]-ACh showed a significant reduction in nicotine and ACh binding sites in cerebral cortex of patients suffering from AD, demonstrating a decrease of both nAChR and mAChR populations (Gotti et al., 2006a; Paterson and Nordberg, 2000; Perry et al., 1981, 1985, 1987, 1988; Shimohama et al., 1986; Whitehouse et al., 1981, 1982, 1986) PubMed:25514383

a(CHEBI:acetylcholine) increases act(p(FPLX:CHRM)) View Subject | View Object

We now realize that acetylcholine liberated from cholinergic nerve terminals often activates both nAChRs and muscarinic receptors PubMed:21482353

Out-Edges 8

p(FPLX:CHRM) regulates a(MESH:"Ion Channels") View Subject | View Object

Muscarinic receptors are G protein coupled receptors that are capable of modulating a wide variety of ion channels PubMed:26813123

p(FPLX:CHRM) regulates act(a(MESH:"Calcium Channels")) View Subject | View Object

As a consequence, stimulation of ACh muscarinic receptors can promote the opening or closing of Ca2+, K+, or Cl- channels, which might facilitate either depolarization or hyperpolarization, depending on the cell type where these receptors are expressed PubMed:26813123

p(FPLX:CHRM) regulates act(a(MESH:"Potassium Channels")) View Subject | View Object

As a consequence, stimulation of ACh muscarinic receptors can promote the opening or closing of Ca2+, K+, or Cl- channels, which might facilitate either depolarization or hyperpolarization, depending on the cell type where these receptors are expressed PubMed:26813123

act(p(FPLX:CHRM)) decreases act(a(MESH:"Potassium Channels")) View Subject | View Object

Activation of muscarinic receptors can block various types of K+ currents by inhibiting many resting and voltage-gated K+ channels PubMed:26813123

p(FPLX:CHRM) regulates act(a(MESH:"Chloride Channels")) View Subject | View Object

As a consequence, stimulation of ACh muscarinic receptors can promote the opening or closing of Ca2+, K+, or Cl- channels, which might facilitate either depolarization or hyperpolarization, depending on the cell type where these receptors are expressed PubMed:26813123

act(p(FPLX:CHRM)) decreases bp(GO:"synaptic transmission, glutamatergic") View Subject | View Object

In addition to decreasing K+ currents, muscarinic receptors located at the presynaptic region can also inhibit GABAergic neurotransmission PubMed:26813123

p(FPLX:CHRM) regulates bp(GO:cognition) View Subject | View Object

The neurotransmitter ACh binds to two families of receptors, nicotinic acetylcholine receptors (nAChRs) and muscarinic acetylcholine receptors (mAChRs). Both families of receptors regulate the cognitive processes mentioned above (Ghoneim and Mewaldt, 1977; Petersen, 1977; Sarter and Paolone, 2011), and are both affected in AD PubMed:25514383

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.