The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.
Genes in the mTOR pathway were also of specific interest because this pathway is inhibited by the immunosuppressant drug rapamy- cin via complex formation with FKBP1b/1a. PubMed:29255009
Nevertheless, the lack of change in mTOR pathway gene expression suggests that FKBP1b’s genomic effects were not mediated by the mTOR pathway. PubMed:29255009
MAP2: downregulation with aging and restoration by FKBP1b PubMed:29255009
Cpn-1 (calpain-1) and Ppp3cc (calcineurin, Nixon et al., 1994; Rozkalne et al., 2011; Furman and Norris, 2014), as well as a Ca2 release-activated Ca2 channel (ORAI1) were altered by aging and restored by FKBP1b treatment (Table 3). PubMed:29255009
Cpn-1 (calpain-1) and Ppp3cc (calcineurin, Nixon et al., 1994; Rozkalne et al., 2011; Furman and Norris, 2014), as well as a Ca2 release-activated Ca2 channel (ORAI1) were altered by aging and restored by FKBP1b treatment (Table 3). PubMed:29255009
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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.