p(MGI:Fkbp1b)
Nevertheless, the lack of change in mTOR pathway gene expression suggests that FKBP1b’s genomic effects were not mediated by the mTOR pathway. PubMed:29255009
AAV-FKBP1b injection increased hippocampal FKBP1b protein and gene expression, particularly in the LT group PubMed:29255009
FKBP1b overexpression improved spatial reference and reversal memory for both LT and ST aged groups PubMed:29255009
Remarkably, only four of the 876 aging-dependent and FKBP1b- sensitive genes (Eif3g, Pla2g7, S100, and Snapc2) exhibited exac- erbation of aging effects by FKBP1b, whereas the other 872 changed in opposite directions with aging and FKBP1b treatment. PubMed:29255009
Remarkably, only four of the 876 aging-dependent and FKBP1b- sensitive genes (Eif3g, Pla2g7, S100, and Snapc2) exhibited exac- erbation of aging effects by FKBP1b, whereas the other 872 changed in opposite directions with aging and FKBP1b treatment. PubMed:29255009
Remarkably, only four of the 876 aging-dependent and FKBP1b- sensitive genes (Eif3g, Pla2g7, S100, and Snapc2) exhibited exac- erbation of aging effects by FKBP1b, whereas the other 872 changed in opposite directions with aging and FKBP1b treatment. PubMed:29255009
Remarkably, only four of the 876 aging-dependent and FKBP1b- sensitive genes (Eif3g, Pla2g7, S100, and Snapc2) exhibited exac- erbation of aging effects by FKBP1b, whereas the other 872 changed in opposite directions with aging and FKBP1b treatment. PubMed:29255009
Remarkably, only four of the 876 aging-dependent and FKBP1b- sensitive genes (Eif3g, Pla2g7, S100, and Snapc2) exhibited exac- erbation of aging effects by FKBP1b, whereas the other 872 changed in opposite directions with aging and FKBP1b treatment. PubMed:29255009
Genes downregulated with aging and upregulated by FKBP1b (AC downregulated vs YC, FKBP1b upregulated vs AC, template II) strongly overrepresented GO categories related to intracellular and extracellular structure, including: cytoskeleton, extracellular region passive transmembrane transporter activity, ectoderm devel- opment, regulation of actin cytoskeleton organization, and regulation of MAP kinase activity (Table 1) PubMed:29255009
Genes downregulated with aging and upregulated by FKBP1b (AC downregulated vs YC, FKBP1b upregulated vs AC, template II) strongly overrepresented GO categories related to intracellular and extracellular structure, including: cytoskeleton, extracellular region passive transmembrane transporter activity, ectoderm devel- opment, regulation of actin cytoskeleton organization, and regulation of MAP kinase activity (Table 1) PubMed:29255009
Genes downregulated with aging and upregulated by FKBP1b (AC downregulated vs YC, FKBP1b upregulated vs AC, template II) strongly overrepresented GO categories related to intracellular and extracellular structure, including: cytoskeleton, extracellular region passive transmembrane transporter activity, ectoderm devel- opment, regulation of actin cytoskeleton organization, and regulation of MAP kinase activity (Table 1) PubMed:29255009
Genes downregulated with aging and upregulated by FKBP1b (AC downregulated vs YC, FKBP1b upregulated vs AC, template II) strongly overrepresented GO categories related to intracellular and extracellular structure, including: cytoskeleton, extracellular region passive transmembrane transporter activity, ectoderm devel- opment, regulation of actin cytoskeleton organization, and regulation of MAP kinase activity (Table 1) PubMed:29255009
Genes upregulated with aging and downregulated by FKBP1b (AC upregulated vs YC, FKBP1b downregulated vs AC, template IV) overrepresented GO category annotations related to extracel- lular remodeling and transporter activity, including extracellular matrix, primary transmembrane transporter activity, blood vessel development, regulation of cell motion, and membrane-bounded vesicle (Table 1) PubMed:29255009
Genes upregulated with aging and downregulated by FKBP1b (AC upregulated vs YC, FKBP1b downregulated vs AC, template IV) overrepresented GO category annotations related to extracel- lular remodeling and transporter activity, including extracellular matrix, primary transmembrane transporter activity, blood vessel development, regulation of cell motion, and membrane-bounded vesicle (Table 1) PubMed:29255009
Genes upregulated with aging and downregulated by FKBP1b (AC upregulated vs YC, FKBP1b downregulated vs AC, template IV) overrepresented GO category annotations related to extracel- lular remodeling and transporter activity, including extracellular matrix, primary transmembrane transporter activity, blood vessel development, regulation of cell motion, and membrane-bounded vesicle (Table 1) PubMed:29255009
Genes upregulated with aging and downregulated by FKBP1b (AC upregulated vs YC, FKBP1b downregulated vs AC, template IV) overrepresented GO category annotations related to extracel- lular remodeling and transporter activity, including extracellular matrix, primary transmembrane transporter activity, blood vessel development, regulation of cell motion, and membrane-bounded vesicle (Table 1) PubMed:29255009
Because FKBP1b is a negative regulator of hippocampal neuronal Ca2 transients PubMed:29255009
Cpn-1 (calpain-1) and Ppp3cc (calcineurin, Nixon et al., 1994; Rozkalne et al., 2011; Furman and Norris, 2014), as well as a Ca2 release-activated Ca2 channel (ORAI1) were altered by aging and restored by FKBP1b treatment (Table 3). PubMed:29255009
Cpn-1 (calpain-1) and Ppp3cc (calcineurin, Nixon et al., 1994; Rozkalne et al., 2011; Furman and Norris, 2014), as well as a Ca2 release-activated Ca2 channel (ORAI1) were altered by aging and restored by FKBP1b treatment (Table 3). PubMed:29255009
Twenty-four mTOR pathway genes were identified by searching the GO data- base and the literature (Johnson et al., 2013). Of these 24, only two, Hif1an and Nfkb1, were significantly altered with both age (upregulated) and FKBP1b (downregulated), showing that the mTOR pathway was not statistically overrepresented by FKBP1b- sensitive genes (n.s., p 0.78, binomial test). PubMed:29255009
Twenty-four mTOR pathway genes were identified by searching the GO data- base and the literature (Johnson et al., 2013). Of these 24, only two, Hif1an and Nfkb1, were significantly altered with both age (upregulated) and FKBP1b (downregulated), showing that the mTOR pathway was not statistically overrepresented by FKBP1b- sensitive genes (n.s., p 0.78, binomial test). PubMed:29255009
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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.