Upload at 2019-02-27 16:20:49.564335
Rana Aldisi
CC BY 4.0
Copyright © 2018 Fraunhofer Institute SCAI, All rights reserved
Number Nodes
Number Edges
Number Components
Network Density
Average Degree
Number Citations
Number BEL Errors

Content Statistics

Network Overlap

The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.

Network Overlap
Interplay of neurotransmitters in Alzheimer's disease v1.0.0 25%
The Nicotinic Acetylcholine Receptor: The Founding Father of the Pentameric Ligand-gated Ion Channel Superfamily v1.0.1 24%
Chronic Anatabine Treatment Reduces Alzheimer ’ s Disease (AD)-Like Pathology and Improves Socio-Behavioral Deficits in a Transgenic Mouse Model of AD v1.0.0 20%
Identification of a novel aspartic protease (Asp 2) as beta-secretase v1.0.0 20%
Effects of peptides derived from BACE1 catalytic domain on APP processing v1.0.0 20%
Alzheimer's Disease: Targeting the Cholinergic System v1.0.0 19%
NACHO Mediates Nicotinic Acetylcholine Receptor Function throughout the Brain v1.0.0 19%
Analysis of Isoform-specific Tau Aggregates Suggests a Common Toxic Mechanism Involving Similar Pathological Conformations and Axonal Transport Inhibition v1.0.1 18%
Tau Antibody Targeting Pathological Species Blocks Neuronal Uptake and Interneuron Propagation of Tau in Vitro v1.0.0 18%
Posiphen as a candidate drug to lower CSF amyloid precursor protein, amyloid-b peptide and s levels: target engagement, tolerability and pharmacokinetics in humans v0.1.0 18%

Sample Edges

a(CHEBI:donepezil) increases act(a(MESH:D005625)) View Subject | View Object

A recent functional MRI study demonstrated that people with MCI treated with the FDA-approved anticholinesterase donepezil demonstrated increased frontal cortex activation relative to untreated controls, which was positively correlated with task performance [31]. PubMed:18986241

Cognitive Dysfunction

a(CHEBI:physostigmine) decreases path(MESH:D000544) View Subject | View Object

Notably, reports that physostigmine and oral anticholinesterases have beneficial effects for patients with AD suggest that the CBF system is somewhat preserved during the progression of dementia, despite well-documented loss of cholinergic biosynthetic machinery (including ChAT and AChE enzyme deficits) in patients with this disease. Interestingly, recent studies have shown that ChAT activity, which results in acetylcholine (ACh) synthesis, is preserved in the neocortex of people with MCI [18,19]. PubMed:18986241

Disease Ontology (DO)
Alzheimer's disease

Sample Nodes


In-Edges: 423 | Out-Edges: 245 | Children: 5 | Explore Neighborhood | Download JSON


In-Edges: 106 | Out-Edges: 69 | Explore Neighborhood | Download JSON


In-Edges: 65 | Out-Edges: 39 | Explore Neighborhood | Download JSON


In-Edges: 477 | Out-Edges: 480 | Classes: 11 | Children: 27 | Explore Neighborhood | Download JSON

p(HGNC:MAPT, pmod(Ph))

In-Edges: 201 | Out-Edges: 71 | Classes: 1 | Children: 4 | Explore Neighborhood | Download JSON


BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.