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  3. Neuropathogenic role of adenylate kinase-1 in Aβ-mediated tau phosphorylation via AMPK and GSK3β. v1.0.0
  4. Biogrammar

Biogrammar Summary of Neuropathogenic role of adenylate kinase-1 in Aβ-mediated tau phosphorylation via AMPK and GSK3β. 1.0.0

Table of Contents

  1. Regulatory Pairs
  2. Contradictory Pairs
  3. Causal Pathologies

Regulatory Pairs 1

These pairs of nodes represent motifs like A increases B and B decreases A.

Node A Node B
a(CHEBI:"amyloid-beta polypeptide 42") p(HGNC:AK1)

Contradictory Statements 1

These pairs of nodes have a contradiction in their causal relationships, meaning they have more than one of INCREASES, DECREASES, or CAUSES NO CHANGE. This may be due to different experimental conditions, so these statements need to be carefully considered in analyses.

Source Relations Target
a(CHEBI:"amyloid-beta polypeptide 42") decreases, causesNoChange p(ECCODE:"2.7.11.31")

Causal Pathologies 4

Pathologies are more dogmatically the result of molecular and physical processes, and do not necessarily make sense as the subject of causal statements.

Source Relation Target
path(MESH:"Alzheimer Disease") decreases p(ECCODE:"2.7.11.31", pmod(Ph, Thr, 172))
path(MESH:"Alzheimer Disease") increases p(HGNC:AK1)
path(MESH:"Alzheimer Disease") increases p(HGNC:MAPT, pmod(Ph, Ser, 396))
path(MESH:"Alzheimer Disease") increases p(HGNC:MAPT, pmod(Ph, Ser, 404))

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.