1. Catalog
  2. Networks
  3. Amyloid Precursor Protein Trafficking, Processing, and Function v1.0.0

Amyloid Precursor Protein Trafficking, Processing, and Function 1.0.0

Compilation Biogrammar
Explore Query

Provenance

Upload
charles.hoyt@scai.fraunhofer.de at 2019-02-27 16:11:59.189360
Authors
Esther Wollert
Contact
charles.hoyt@scai.fraunhofer.de
Description
Amyloid Precursor Protein Trafficking, Processing, and Function by Thinakaran, et al., 2008
License
CC BY 4.0
Copyright
Copyright © 2018 Fraunhofer Institute SCAI, All rights reserved.
Number Nodes
40
Number Edges
48
Number Components
1
Network Density
0.0307692307692308
Average Degree
1.2
Number Citations
1
Number BEL Errors
0

Content Statistics

Network Overlap

The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.

Network Overlap
APP processing in Alzheimer's disease v1.0.1 62%
Proteolytic processing of Alzeimer's beta-amyloid precursor protein v1.0.1 50%
Identification of a novel aspartic protease (Asp 2) as beta-secretase v1.0.0 30%
Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0 22%
Effects of peptides derived from BACE1 catalytic domain on APP processing v1.0.0 20%
The Ubiquitin Proteasome System in Neurodegenerative Diseases: Sometimes the Chicken, Sometimes the Egg v1.0.0 20%
Increased NF-κB signalling up-regulates BACE1 expression and its therapeutic potential in Alzheimer's disease. v1.0.0 20%
Nicotinic acetylcholine receptor signalling: roles in Alzheimer's disease and amyloid neuroprotection. v1.0.0 18%
Alzheimer's Disease: Targeting the Cholinergic System v1.0.0 18%
M1 muscarinic acetylcholine receptor in Alzheimer’s disease v1.0.0 18%

Sample Edges

a(CHEBI:"amyloid-beta") increases bp(GO:"cell adhesion") View Subject | View Object

Interestingly, because the RHDS sequence is contained within the N terminus of Aβ, similar cell adhesion-promoting properties have also been attributed to the Aβ peptide itself. PubMed:18650430

Annotations
Confidence
Medium

a(MESH:"Amyloid beta-Peptides") increases bp(GO:"cell adhesion") View Subject | View Object

Interestingly, because the RHDS sequence is contained within the N terminus of Aβ, similar cell adhesion-promoting properties have also been attributed to the Aβ peptide itself. PubMed:18650430

Annotations
Confidence
Medium

complex(FPLX:"Gamma_secretase") hasComponent p(HGNC:PSEN1) View Subject | View Object

complex(FPLX:"Gamma_secretase") hasComponent p(HGNC:PSEN2) View Subject | View Object

complex(FPLX:"Gamma_secretase") hasComponent p(HGNC:NCSTN) View Subject | View Object

Sample Nodes

a(CHEBI:"amyloid-beta")

In-Edges: 423 | Out-Edges: 245 | Children: 5 | Explore Neighborhood | Download JSON

a(HBP:HBP00018)

In-Edges: 35 | Out-Edges: 8 | Explore Neighborhood | Download JSON

bp(GO:"cell adhesion")

In-Edges: 11 | Out-Edges: 5 | Explore Neighborhood | Download JSON

path(MESH:"Alzheimer Disease")

In-Edges: 536 | Out-Edges: 704 | Classes: 5 | Explore Neighborhood | Download JSON

p(HGNC:APP)

In-Edges: 106 | Out-Edges: 69 | Explore Neighborhood | Download JSON

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.