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Appears in Networks 7

In-Edges 11

bp(GO:aging) association bp(GO:"cell adhesion") View Subject | View Object

Enrichment analysis revealed, however, changes in gene sets involved in immune and inflammatory responses, phospholipid metabolism, extracellular matrix organization, cellular adhesion and endothelial tube morphogenesis, all of which suggest that there are functional alterations in meningeal LECs with age (Fig. 2c). PubMed:30046111

a(CHEBI:"amyloid-beta") increases bp(GO:"cell adhesion") View Subject | View Object

Interestingly, because the RHDS sequence is contained within the N terminus of Aβ, similar cell adhesion-promoting properties have also been attributed to the Aβ peptide itself. PubMed:18650430

a(MESH:"Amyloid beta-Peptides") increases bp(GO:"cell adhesion") View Subject | View Object

Interestingly, because the RHDS sequence is contained within the N terminus of Aβ, similar cell adhesion-promoting properties have also been attributed to the Aβ peptide itself. PubMed:18650430

p(HGNC:APP) increases bp(GO:"cell adhesion") View Subject | View Object

An RHDS motif near the extralumenal por- tion of APP or at the C terminus of APPs lying within the Aβ region appears to promote cell adhesion. PubMed:18650430

p(HGNC:APP) association bp(GO:"cell adhesion") View Subject | View Object

A role for APP has been suggested in neurite outgrowth and synaptogenesis, neuronal protein trafficking along the axon, transmembrane signal transduction, cell adhesion, calcium metabolism, etc, all requiring additional in vivo evidence (reviewed in [19]) PubMed:21214928

Annotations
Confidence
High

a(HBP:HBP00067) increases bp(GO:"cell adhesion") View Subject | View Object

sAPP-alpha is thought to promote neurite outgrowth and synaptogenesis as well as cell adhesion (Mattson 1997; Gakhar Koppole et al. 2008) PubMed:22122372

p(HGNC:APP) increases bp(GO:"cell adhesion") View Subject | View Object

Nevertheless, APP is more widely accepted as a protein contributing to cell adhesion via its extracellular domain PubMed:22122372

a(CHEBI:atropine) decreases bp(GO:"cell adhesion") View Subject | View Object

Furthermore, pharmacological dissection of nicotine’s influence on cell cycle progression, apoptosis, and differentiation (43) indicate that alpha7 nAChRs expressed in keratynocytes are important. Other receptors are clearly involved in this process, since atropine, a muscarinic and sometimes nAChR inhibitor (531, 532), reduces cell adhesion through decreasing desmoligein expression. PubMed:19126755

Appears in Networks:
Annotations
MeSH
Keratinocytes
Text Location
Review

a(MESH:Acetylcholine) association bp(GO:"cell adhesion") View Subject | View Object

but ACh is also released by non-neuronal tissues where it is involved in cell-to-cell communication, and con- trols essential functions such as cell proliferation, adhesion, migration, secretion, survival and apoptosis, in an autocrine, paracrine or juxtacrine manner PubMed:28901280

a(PUBCHEM:9832404) association bp(GO:"cell adhesion") View Subject | View Object

Additionally, given that ADNP and NAP are linked with autophagy (13), cell adhesion (35), immune response (36), autism (6, 13, 15, 17, 27), and synapse-related processes (6), the analysis included several representative genes pertaining to these processes PubMed:30106381

p(HGNC:ADNP) association bp(GO:"cell adhesion") View Subject | View Object

Additionally, given that ADNP and NAP are linked with autophagy (13), cell adhesion (35), immune response (36), autism (6, 13, 15, 17, 27), and synapse-related processes (6), the analysis included several representative genes pertaining to these processes PubMed:30106381

Out-Edges 5

bp(GO:"cell adhesion") association bp(GO:aging) View Subject | View Object

Enrichment analysis revealed, however, changes in gene sets involved in immune and inflammatory responses, phospholipid metabolism, extracellular matrix organization, cellular adhesion and endothelial tube morphogenesis, all of which suggest that there are functional alterations in meningeal LECs with age (Fig. 2c). PubMed:30046111

bp(GO:"cell adhesion") association p(HGNC:APP) View Subject | View Object

A role for APP has been suggested in neurite outgrowth and synaptogenesis, neuronal protein trafficking along the axon, transmembrane signal transduction, cell adhesion, calcium metabolism, etc, all requiring additional in vivo evidence (reviewed in [19]) PubMed:21214928

Annotations
Confidence
High

bp(GO:"cell adhesion") association a(MESH:Acetylcholine) View Subject | View Object

but ACh is also released by non-neuronal tissues where it is involved in cell-to-cell communication, and con- trols essential functions such as cell proliferation, adhesion, migration, secretion, survival and apoptosis, in an autocrine, paracrine or juxtacrine manner PubMed:28901280

bp(GO:"cell adhesion") association p(HGNC:ADNP) View Subject | View Object

Additionally, given that ADNP and NAP are linked with autophagy (13), cell adhesion (35), immune response (36), autism (6, 13, 15, 17, 27), and synapse-related processes (6), the analysis included several representative genes pertaining to these processes PubMed:30106381

bp(GO:"cell adhesion") association a(PUBCHEM:9832404) View Subject | View Object

Additionally, given that ADNP and NAP are linked with autophagy (13), cell adhesion (35), immune response (36), autism (6, 13, 15, 17, 27), and synapse-related processes (6), the analysis included several representative genes pertaining to these processes PubMed:30106381

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.