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  3. complex(p(HGNC:CHRM1), p(INTERPRO:"G-protein alpha subunit, group Q"))

complex(p(HGNC:CHRM1), p(INTERPRO:"G-protein alpha subunit, group Q"))

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Components

Appears in Networks 1

Alzheimer's Disease: Targeting the Cholinergic System v1.0.0

In-Edges 1

path(MESH:"Alzheimer Disease") negativeCorrelation complex(p(HGNC:CHRM1), p(INTERPRO:"G-protein alpha subunit, group Q")) View Subject | View Object

It has been demonstrated that M1 muscarinic receptors coupling to G-proteins is impaired in the neocortex of AD patients and that the extent of M1/G-protein uncoupling is related to the severity of cognitive symptoms in AD PubMed:26813123

Appears in Networks:
Annotations
MeSH
Neocortex
MeSH
Alzheimer Disease

Out-Edges 8

complex(p(HGNC:CHRM1), p(INTERPRO:"G-protein alpha subunit, group Q")) hasComponent p(HGNC:CHRM1) View Subject | View Object

Appears in Networks:

complex(p(HGNC:CHRM1), p(INTERPRO:"G-protein alpha subunit, group Q")) hasComponent p(INTERPRO:"G-protein alpha subunit, group Q") View Subject | View Object

Appears in Networks:

complex(p(HGNC:CHRM1), p(INTERPRO:"G-protein alpha subunit, group Q")) increases act(p(FPLX:PLC)) View Subject | View Object

Stimulation of Gαq coupled muscarinic receptors leads to activation of phospholipase C and formation of inositol phosphates and other second messengers, which can promote closure of K+ channels, thus facilitating cell excitability PubMed:26813123

Appears in Networks:

complex(p(HGNC:CHRM1), p(INTERPRO:"G-protein alpha subunit, group Q")) increases a(CHEBI:"myo-inositol") View Subject | View Object

Stimulation of Gαq coupled muscarinic receptors leads to activation of phospholipase C and formation of inositol phosphates and other second messengers, which can promote closure of K+ channels, thus facilitating cell excitability PubMed:26813123

Appears in Networks:

complex(p(HGNC:CHRM1), p(INTERPRO:"G-protein alpha subunit, group Q")) decreases act(a(MESH:"Potassium Channels")) View Subject | View Object

Stimulation of Gαq coupled muscarinic receptors leads to activation of phospholipase C and formation of inositol phosphates and other second messengers, which can promote closure of K+ channels, thus facilitating cell excitability PubMed:26813123

Appears in Networks:

complex(p(HGNC:CHRM1), p(INTERPRO:"G-protein alpha subunit, group Q")) increases a(MESH:"Receptors, N-Methyl-D-Aspartate") View Subject | View Object

On the other hand, stimulation of Gαq coupled muscarinic receptors generates intracellular second messengers that can facilitate N-methyl-D-aspartate (NMDA) currents PubMed:26813123

Appears in Networks:

complex(p(HGNC:CHRM1), p(INTERPRO:"G-protein alpha subunit, group Q")) negativeCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

It has been demonstrated that M1 muscarinic receptors coupling to G-proteins is impaired in the neocortex of AD patients and that the extent of M1/G-protein uncoupling is related to the severity of cognitive symptoms in AD PubMed:26813123

Appears in Networks:
Annotations
MeSH
Neocortex
MeSH
Alzheimer Disease

complex(p(HGNC:CHRM1), p(INTERPRO:"G-protein alpha subunit, group Q")) increases bp(GO:cognition) View Subject | View Object

It has been demonstrated that M1 muscarinic receptors coupling to G-proteins is impaired in the neocortex of AD patients and that the extent of M1/G-protein uncoupling is related to the severity of cognitive symptoms in AD PubMed:26813123

Appears in Networks:
Annotations
MeSH
Neocortex
MeSH
Alzheimer Disease

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.