a(CHEBI:"amyloid-beta") decreases sec(a(PUBCHEM:16057918))

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PubMed:28745240

Recent evidence has cogently shown that Amyloid-β induces apoptosis in rat primary neurons and human post-mitotic neuronal cells by reducing Bcl-XL expression level and evoking the release of cytochrome c from the mitochondria in a NF-κB – dependent manner

Related Edges 6

• a(CHEBI:"amyloid-beta") increases bp(GO:"apoptotic process")
• a(CHEBI:"amyloid-beta") increases act(complex(GO:"NF-kappaB complex"))
• a(CHEBI:"amyloid-beta") decreases p(HGNC:BCL2L1)
• complex(GO:"NF-kappaB complex") decreases p(HGNC:BCL2L1)
• complex(GO:"NF-kappaB complex") decreases sec(a(PUBCHEM:16057918))
• p(HGNC:BCL2L1) increases sec(a(PUBCHEM:16057918))

MeSH

Mitochondria

MeSH

Alzheimer Disease

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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