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Mitochondria

Name
Mitochondria
Namespace Keyword
MeSHAnatomy
Namespace
MeSH
Namespace Version
20170511
Namespace URL
https://arty.scai.fraunhofer.de/artifactory/bel/annotation/mesh-anatomy/mesh-anatomy-20170511.belanno

Sample Annotated Edges 5

p(HGNC:HSPD1) association bp(MESH:"Energy Metabolism") View Subject | View Object

HSP60 is essential for maturation and maintenance of the mitochondrial proteome and is therefore intimately linked to energy production. PubMed:25784053

Appears in Networks:
Annotations
MeSH
Mitochondria

p(HGNC:HSPD1) increases bp(HBP:Proteostasis) View Subject | View Object

HSP60 is essential for maturation and maintenance of the mitochondrial proteome and is therefore intimately linked to energy production. PubMed:25784053

Appears in Networks:
Annotations
MeSH
Mitochondria

bp(MESH:"Energy Metabolism") association p(HGNC:HSPD1) View Subject | View Object

HSP60 is essential for maturation and maintenance of the mitochondrial proteome and is therefore intimately linked to energy production. PubMed:25784053

Appears in Networks:
Annotations
MeSH
Mitochondria

p(HBP:"UBB+1") increases bp(MESH:"Stress, Physiological") View Subject | View Object

UBB+ 1-capped polyUb chains are resistant to deubiquitination and inhibit proteasomal activity, which may mediate neurodegeneration through mitochondrial stress and p53 activation in neurites (Tan et al., 2007). PubMed:23528736

Appears in Networks:
Annotations
MeSH
Mitochondria
MeSH
Neurites

bp(GO:"response to unfolded protein") regulates bp(HBP:Proteostasis) View Subject | View Object

The PN is regulated by interconnected pathways that respond to specific forms of cellular stress, including the cytosolic heat shock response (HSR) (191), the unfolded protein response (UPR) in the endoplas- mic reticulum (192), and the mitochondrial UPR (193). PubMed:23746257

Appears in Networks:
Annotations
MeSH
Endoplasmic Reticulum
MeSH
Mitochondria

Showing 5 of 61 edges

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.