m(MIRBASE:"rno-mir-195") negativeCorrelation p(RGD:Bace1)

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PubMed:26118667

Chronic Brain hypoperfusion (CBH) elevates nuclear factor-kB (NF-kB), which binds with the promoter sequences of miR-195 and negatively regulates its expression. Down-regulated miR-195 up-regulates APP and BACE1 and increases Aß levels. Some Aß then enter the intracellular space and activate calpain, promoting the conversion of Cdk5/p35 to Cdk5/p25 and catalyzes the degradation of IkB (inhibitor of NF-?B)and directly phosphorylates Tau. Down-regulated miR-195 up-regulates p35, which provides the active substrates of p25

Related Edges 13

• a(CHEBI:"amyloid-beta") negativeCorrelation m(MIRBASE:"rno-mir-195")
• a(CHEBI:"amyloid-beta") increases p(INTERPRO:"Peptidase C2, calpain, catalytic domain")
• a(HBP:"Chronic cerebral hypoperfusion") increases p(FPLX:NFkappaB)
• complex(g(MIRBASE:"rno-mir-195"), p(FPLX:NFkappaB)) decreases m(MIRBASE:"rno-mir-195")
• p(FPLX:NFkappaB) increases complex(g(MIRBASE:"rno-mir-195"), p(FPLX:NFkappaB))
• m(MIRBASE:"rno-mir-195") negativeCorrelation p(RGD:App)
• m(MIRBASE:"rno-mir-195") negativeCorrelation a(CHEBI:"amyloid-beta")
• m(MIRBASE:"rno-mir-195") negativeCorrelation p(RGD:Cdk5r1)
• p(INTERPRO:"Peptidase C2, calpain, catalytic domain") positiveCorrelation act(p(RGD:Cdk5r1))
• p(RGD:App) negativeCorrelation m(MIRBASE:"rno-mir-195")
• p(RGD:Bace1) negativeCorrelation m(MIRBASE:"rno-mir-195")
• act(p(RGD:Cdk5r1)) positiveCorrelation p(INTERPRO:"Peptidase C2, calpain, catalytic domain")
• p(RGD:Cdk5r1) negativeCorrelation m(MIRBASE:"rno-mir-195")

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