a(CHEBI:Temsirolimus) decreases a(HBP:HBP00016)

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PubMed:30116051

It also removed cellular aggregates of mutant Htt and improved motor performance in a mouse model of HD, reduced α-synuclein aggregation and afforded neuroprotection in a lesion-based model of PD and depleted mutant ataxin 3 in a mouse model of supraspinal cerebellar ataxia type 3 (REFS133,138,139) .

Related Edges 4

• a(CHEBI:Temsirolimus) decreases a(HBP:HBP00017)
• a(CHEBI:Temsirolimus) increases bp(GO:"motor behavior")
• a(CHEBI:Temsirolimus) decreases bp(HP:Neurodegeneration)
• a(CHEBI:Temsirolimus) decreases p(HGNC:ATXN3, var("?"))

MeSH

Dopaminergic Neurons

MeSH

Parkinson Disease

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