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Dopaminergic Neurons

Name
Dopaminergic Neurons
Namespace Keyword
MeSHAnatomy
Namespace
MeSH
Namespace Version
20170511
Namespace URL
https://arty.scai.fraunhofer.de/artifactory/bel/annotation/mesh-anatomy/mesh-anatomy-20170511.belanno

Sample Annotated Edges 5

path(MESH:Hypokinesia) positiveCorrelation path(MESH:"Parkinson Disease") View Subject | View Object

Parkinson’s disease (PD) is characterized by selective damage to dopaminergic nigrostriatal neurons and is clinically revealed by motor deficits, including rigidity, tremor, and bradykinesia. Dopamine replacement therapy (usually with L-dopa) is the most common treatment, although this drug loses efficacy over time. PubMed:19126755

Appears in Networks:
Annotations
MeSH
Dopaminergic Neurons
Text Location
Review

act(p(HGNC:CHRNA7)) increases a(CHEBI:dopamine, loc(GO:"extracellular region")) View Subject | View Object

As illustrated in Figure 8, KYNA-induced reduction of extracellular dopamine levels can be explained by the inhibition of tonically active alpha7 nAChRs in the dopaminergic neurons within the VTA and/or in cortical glutamatergic terminals that synapse onto striatal neurons. VTA dopaminergic neurons represent the major dopaminergic input to the nucleus accumbens. PubMed:19126755

Appears in Networks:
Annotations
MeSH
Dopaminergic Neurons
Text Location
Review

path(MESH:"Muscle Rigidity") positiveCorrelation path(MESH:"Parkinson Disease") View Subject | View Object

Parkinson’s disease (PD) is characterized by selective damage to dopaminergic nigrostriatal neurons and is clinically revealed by motor deficits, including rigidity, tremor, and bradykinesia. Dopamine replacement therapy (usually with L-dopa) is the most common treatment, although this drug loses efficacy over time. PubMed:19126755

Appears in Networks:
Annotations
MeSH
Dopaminergic Neurons
Text Location
Review

a(CHEBI:dopamine) decreases path(MESH:"Parkinson Disease") View Subject | View Object

Parkinson’s disease (PD) is characterized by selective damage to dopaminergic nigrostriatal neurons and is clinically revealed by motor deficits, including rigidity, tremor, and bradykinesia. Dopamine replacement therapy (usually with L-dopa) is the most common treatment, although this drug loses efficacy over time. PubMed:19126755

Appears in Networks:
Annotations
MeSH
Dopaminergic Neurons
Text Location
Review

path(MESH:Tremor) positiveCorrelation path(MESH:"Parkinson Disease") View Subject | View Object

Parkinson’s disease (PD) is characterized by selective damage to dopaminergic nigrostriatal neurons and is clinically revealed by motor deficits, including rigidity, tremor, and bradykinesia. Dopamine replacement therapy (usually with L-dopa) is the most common treatment, although this drug loses efficacy over time. PubMed:19126755

Appears in Networks:
Annotations
MeSH
Dopaminergic Neurons
Text Location
Review

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.