p(MGI:Crhr1) positiveCorrelation a(HBP:"Tau aggregates")

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PubMed:25125464

CRF-OE mice had significantly elevated tau-P compared to wild type (WT) mice at the AT8 (S202/T204), PHF-1 (S396/404), S262, and S422 sites. Treating CRF-OE mice with R121919 blocked phosphorylation at the AT8 (S202/T204) and PHF-1 (S396/404) sites, but not at the S262 and S422 sites and reduced phosphorylation of c-Jun N Terminal Kinase (JNK).

Related Edges 13

• a(HBP:"Tau aggregates") positiveCorrelation p(MGI:Crhr1)
• a(HBP:"Tau epitope, PHF1") positiveCorrelation p(MGI:Crhr1)
• p(HBP:"Tau epitope, AT8") positiveCorrelation p(MGI:Crhr1)
• p(MGI:Crh) increases p(HBP:"Tau epitope, AT8")
• p(MGI:Crh) increases a(HBP:"Tau epitope, PHF1")
• p(MGI:Crh) positiveCorrelation p(MGI:Mapt, pmod(Ph, Ser, 262))
• p(MGI:Crh) positiveCorrelation p(MGI:Mapt, pmod(Ph, Ser, 422))
• p(MGI:Crhr1) positiveCorrelation p(HBP:"Tau epitope, AT8")
• p(MGI:Crhr1) positiveCorrelation a(HBP:"Tau epitope, PHF1")
• p(MGI:Crhr1) positiveCorrelation p(MGI:Mapk8)
• p(MGI:Mapk8) positiveCorrelation p(MGI:Crhr1)
• p(MGI:Mapt, pmod(Ph, Ser, 262)) positiveCorrelation p(MGI:Crh)
• p(MGI:Mapt, pmod(Ph, Ser, 422)) positiveCorrelation p(MGI:Crh)

Uberon

hippocampal formation

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