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PubMed: 25125464

Title
Increased tau phosphorylation and aggregation in the hippocampus of mice overexpressing corticotropin-releasing factor.
Journal
Journal of Alzheimer's disease : JAD
Volume
43
Issue
None
Pages
967-76
Date
2015-01-01
Authors
Campbell SN | Masliah E | Monte L | Rice KC | Rissman RA | Roe AD | Taché Y | Zhang C

Evidence a7b5423606
JSON

Analysis of synaptosomes revealed that FynCA accumulated at high levels in the spine, resulting in increased levels of the NMDA receptor subunit NR2b phosphorylated at residue Y1472. Tau was strongly phosphorylated at the AT8 epitope S202/T205 as shown by Western blot and immunohistochemistry indicating that an increased tyrosine kinase activity of Fyn has down-stream consequences for serine/threonine-directed phosphorylation.

a(GO:"neuron spine") positiveCorrelation p(MGI:Fyn) View Subject | View Object

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p(MGI:Fyn) positiveCorrelation a(GO:"neuron spine") View Subject | View Object

Appears in Networks:

act(p(MGI:Fyn)) increases p(MGI:Grin2b, pmod(Ph, Tyr, 1472)) View Subject | View Object

Appears in Networks:

act(p(MGI:Fyn)) increases p(HBP:"Tau epitope, AT8") View Subject | View Object

Appears in Networks:

Evidence 4a49dfeb06
JSON

CRF-OE mice had significantly elevated tau-P compared to wild type (WT) mice at the AT8 (S202/T204), PHF-1 (S396/404), S262, and S422 sites. Treating CRF-OE mice with R121919 blocked phosphorylation at the AT8 (S202/T204) and PHF-1 (S396/404) sites, but not at the S262 and S422 sites and reduced phosphorylation of c-Jun N Terminal Kinase (JNK).

a(HBP:"Tau aggregates") positiveCorrelation p(MGI:Crhr1) View Subject | View Object

Appears in Networks:
Annotations
Uberon
hippocampal formation

a(HBP:"Tau epitope, PHF1") positiveCorrelation p(MGI:Crhr1) View Subject | View Object

Appears in Networks:
Annotations
Uberon
hippocampal formation

p(HBP:"Tau epitope, AT8") positiveCorrelation p(MGI:Crhr1) View Subject | View Object

Appears in Networks:
Annotations
Uberon
hippocampal formation

p(MGI:Crh) increases p(HBP:"Tau epitope, AT8") View Subject | View Object

Appears in Networks:
Annotations
Uberon
hippocampal formation

p(MGI:Crh) increases a(HBP:"Tau epitope, PHF1") View Subject | View Object

Appears in Networks:
Annotations
Uberon
hippocampal formation

p(MGI:Crh) positiveCorrelation p(MGI:Mapt, pmod(Ph, Ser, 262)) View Subject | View Object

Appears in Networks:
Annotations
Uberon
hippocampal formation

p(MGI:Crh) positiveCorrelation p(MGI:Mapt, pmod(Ph, Ser, 422)) View Subject | View Object

Appears in Networks:
Annotations
Uberon
hippocampal formation

p(MGI:Crhr1) positiveCorrelation p(HBP:"Tau epitope, AT8") View Subject | View Object

Appears in Networks:
Annotations
Uberon
hippocampal formation

p(MGI:Crhr1) positiveCorrelation a(HBP:"Tau epitope, PHF1") View Subject | View Object

Appears in Networks:
Annotations
Uberon
hippocampal formation

p(MGI:Crhr1) positiveCorrelation p(MGI:Mapk8) View Subject | View Object

Appears in Networks:
Annotations
Uberon
hippocampal formation

p(MGI:Crhr1) positiveCorrelation a(HBP:"Tau aggregates") View Subject | View Object

Appears in Networks:
Annotations
Uberon
hippocampal formation

p(MGI:Mapk8) positiveCorrelation p(MGI:Crhr1) View Subject | View Object

Appears in Networks:
Annotations
Uberon
hippocampal formation

p(MGI:Mapt, pmod(Ph, Ser, 262)) positiveCorrelation p(MGI:Crh) View Subject | View Object

Appears in Networks:
Annotations
Uberon
hippocampal formation

p(MGI:Mapt, pmod(Ph, Ser, 422)) positiveCorrelation p(MGI:Crh) View Subject | View Object

Appears in Networks:
Annotations
Uberon
hippocampal formation

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