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p(MGI:Grin2b, pmod(Ph, Tyr, 1472))

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
Grin2b
Namespace
mgi
Namespace Version
20181021
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/f2f993e599694ab5ce989cc39d789a499f75db99/external/mgi-names.belns

Appears in Networks 1

Tau Modifications v1.9.5

Tau Modifications Sections of NESTOR

In-Edges 2

p(MGI:Grin2b) hasVariant p(MGI:Grin2b, pmod(Ph, Tyr, 1472)) View Subject | View Object

Appears in Networks:

act(p(MGI:Fyn)) increases p(MGI:Grin2b, pmod(Ph, Tyr, 1472)) View Subject | View Object

Analysis of synaptosomes revealed that FynCA accumulated at high levels in the spine, resulting in increased levels of the NMDA receptor subunit NR2b phosphorylated at residue Y1472. Tau was strongly phosphorylated at the AT8 epitope S202/T205 as shown by Western blot and immunohistochemistry indicating that an increased tyrosine kinase activity of Fyn has down-stream consequences for serine/threonine-directed phosphorylation. PubMed:25125464

Appears in Networks:

Out-Edges 0

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.