act(p(MGI:Fyn)) increases p(HBP:"Tau epitope, AT8")

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PubMed:25125464

Analysis of synaptosomes revealed that FynCA accumulated at high levels in the spine, resulting in increased levels of the NMDA receptor subunit NR2b phosphorylated at residue Y1472. Tau was strongly phosphorylated at the AT8 epitope S202/T205 as shown by Western blot and immunohistochemistry indicating that an increased tyrosine kinase activity of Fyn has down-stream consequences for serine/threonine-directed phosphorylation.

Related Edges 3

• a(GO:"neuron spine") positiveCorrelation p(MGI:Fyn)
• p(MGI:Fyn) positiveCorrelation a(GO:"neuron spine")
• act(p(MGI:Fyn)) increases p(MGI:Grin2b, pmod(Ph, Tyr, 1472))

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