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Appears in Networks 1

Tau Modifications v1.9.5

Tau Modifications Sections of NESTOR

In-Edges 3

p(MGI:Dapk1) increases p(MGI:Mapt, pmod(Ph, Ser, 262)) View Subject | View Object

Direct interaction of DAPK1 with Tau causes spine loss and subsequently neuronal death. DAPK1 phosphorylates Tau protein at Ser262 (pS(262)) in cortical neurons of stroke mice. PubMed:25995053

Appears in Networks:
Annotations
Uberon
cerebral cortex
MeSH
Stroke

p(MGI:Crh) positiveCorrelation p(MGI:Mapt, pmod(Ph, Ser, 262)) View Subject | View Object

CRF-OE mice had significantly elevated tau-P compared to wild type (WT) mice at the AT8 (S202/T204), PHF-1 (S396/404), S262, and S422 sites. Treating CRF-OE mice with R121919 blocked phosphorylation at the AT8 (S202/T204) and PHF-1 (S396/404) sites, but not at the S262 and S422 sites and reduced phosphorylation of c-Jun N Terminal Kinase (JNK). PubMed:25125464

Appears in Networks:
Annotations
Uberon
hippocampal formation

Out-Edges 2

p(MGI:Mapt, pmod(Ph, Ser, 262)) decreases a(GO:"dendritic spine") View Subject | View Object

Direct interaction of DAPK1 with Tau causes spine loss and subsequently neuronal death. DAPK1 phosphorylates Tau protein at Ser262 (pS(262)) in cortical neurons of stroke mice. PubMed:25995053

Appears in Networks:
Annotations
Uberon
cerebral cortex
MeSH
Stroke

p(MGI:Mapt, pmod(Ph, Ser, 262)) positiveCorrelation p(MGI:Crh) View Subject | View Object

CRF-OE mice had significantly elevated tau-P compared to wild type (WT) mice at the AT8 (S202/T204), PHF-1 (S396/404), S262, and S422 sites. Treating CRF-OE mice with R121919 blocked phosphorylation at the AT8 (S202/T204) and PHF-1 (S396/404) sites, but not at the S262 and S422 sites and reduced phosphorylation of c-Jun N Terminal Kinase (JNK). PubMed:25125464

Appears in Networks:
Annotations
Uberon
hippocampal formation

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.