act(p(INTERPRO:"Triosephosphate isomerase")) negativeCorrelation a(CHEBI:methylglyoxal)

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PubMed:19251756

In accordance with the decreased efficiency of nitro-TPI we found a significant increase in methylglyoxal production (P50.05), independent of whether DHAP or GAP was used as substrate (Fig. 2E). Thus, nitrotyrosination of TPI results in reduced catalytic activity and increased occupancy of the enzyme by the substrate, and consequently, a higher production of the toxic methylglyoxal.

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• a(CHEBI:methylglyoxal) negativeCorrelation act(p(INTERPRO:"Triosephosphate isomerase"))

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