path(MESH:"Alzheimer Disease") association bp(GO:"neuron death")

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PubMed:22122372

Plaques consisting of beta-amyloid (Abeta) peptide (Selkoe 1998), neurofibrillary tangles consisting largely of hyperphosphorylated microtubule-associated tau protein (Buee et al. 2000; Gendron and Petrucelli 2009) and neuron loss in the hippocampus and cortex regions are the major pathological hallmarks of Alzheimer’s disease.

Related Edges 7

• a(MESH:"Amyloid beta-Peptides") association path(MESH:"Alzheimer Disease")
• bp(GO:"neurofibrillary tangle assembly") association p(HGNC:MAPT, pmod(Ph))
• bp(GO:"neurofibrillary tangle assembly") association path(MESH:"Alzheimer Disease")
• bp(GO:"neuron death") association path(MESH:"Alzheimer Disease")
• p(HGNC:MAPT, pmod(Ph)) association bp(GO:"neurofibrillary tangle assembly")
• path(MESH:"Alzheimer Disease") association a(MESH:"Amyloid beta-Peptides")
• path(MESH:"Alzheimer Disease") association bp(GO:"neurofibrillary tangle assembly")

Confidence

High

MeSH

Cerebral Cortex

MeSH

Hippocampus

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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