act(p(HGNC:NOS2)) increases a(CHEBI:"nitric oxide")

View Subject View Object

PubMed:23702978

In addition, T cell-derived IFNγ has been shown to downregulate the activity of NLRP3 via activation of inducible nitric oxide synthase (iNOS) in a mouse model of tuberculosis71; nitric oxide (NO) induces NLRP3 nitrosylation and thereby inhibits NLRP3 activity.

Related Edges 4

• a(CHEBI:"nitric oxide") increases p(HGNC:NLRP3, pmod(NO))
• p(HGNC:IFNG) decreases act(p(HGNC:NLRP3))
• p(HGNC:IFNG) increases act(p(HGNC:NOS2))
• p(HGNC:NLRP3, pmod(NO)) decreases act(p(HGNC:NLRP3))

Confidence

High

NeuroMMSigDB

Caspase subgraph

NeuroMMSigDB

Interferon signaling subgraph

NeuroMMSigDB

Nitric oxide subgraph

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

---