p(HGNC:IFNG) decreases act(p(HGNC:NLRP3))

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PubMed:23702978

In addition, T cell-derived IFNγ has been shown to downregulate the activity of NLRP3 via activation of inducible nitric oxide synthase (iNOS) in a mouse model of tuberculosis71; nitric oxide (NO) induces NLRP3 nitrosylation and thereby inhibits NLRP3 activity.

Related Edges 4

• a(CHEBI:"nitric oxide") increases p(HGNC:NLRP3, pmod(NO))
• p(HGNC:IFNG) increases act(p(HGNC:NOS2))
• p(HGNC:NLRP3, pmod(NO)) decreases act(p(HGNC:NLRP3))
• act(p(HGNC:NOS2)) increases a(CHEBI:"nitric oxide")

Confidence

High

NeuroMMSigDB

Caspase subgraph

NeuroMMSigDB

Interferon signaling subgraph

NeuroMMSigDB

Nitric oxide subgraph

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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