p(HGNC:EXT2) increases tloc(a(HBP:"Tau oligomers"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular))

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PubMed:29686391

These single gene knockdowns repressed uptake of tau monomer by over 50% (Fig. 2b) and also reduced the uptake of tau oligomers (Fig. 2c)

Related Edges 9

• bp(GO:"heparan sulfate proteoglycan biosynthetic process") association p(HGNC:EXT2)
• bp(GO:"heparan sulfate proteoglycan biosynthetic process") association p(HGNC:HS6ST1)
• p(HGNC:DNM2) increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular))
• p(HGNC:DNM2) increases tloc(a(HBP:"Tau oligomers"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular))
• p(HGNC:EXT2) association bp(GO:"heparan sulfate proteoglycan biosynthetic process")
• p(HGNC:EXT2) increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular))
• p(HGNC:HS6ST1) association bp(GO:"heparan sulfate proteoglycan biosynthetic process")
• p(HGNC:HS6ST1) increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular))
• p(HGNC:HS6ST1) increases tloc(a(HBP:"Tau oligomers"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular))

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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