a(CHEBI:staurosporine) increases bp(GO:"apoptotic process")

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PubMed:27594586

We treated these neurons with staurosporine, a broad-spectrum kinase inhibitor that induces apoptosis (Budd et al., 2000); rotenone, a complex inhibitor that induces mitochondrial dysfunction (Sherer et al., 2003); and rapamycin, an inhibitor of the mammalian target of the rapamycin (mTOR) signaling pathway with many downstream effects (Li et al., 2014)

Related Edges 2

• a(CHEBI:rotenone) increases bp(HBP:HBP00037)
• a(CHEBI:sirolimus) decreases bp(GO:"TOR signaling")

MeSH

Extracellular Space

Confidence

High

MeSH

Cerebral Cortex

MeSH

Neurons

MeSH

Frontotemporal Dementia

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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