Name
Frontotemporal Dementia
Namespace Keyword
MeSHDisease
Namespace
MeSH
Namespace Version
20170511
Namespace URL
https://arty.scai.fraunhofer.de/artifactory/bel/annotation/mesh-diseases/mesh-diseases-20170511.belanno

Sample Annotated Edges 5

p(HGNC:MAPT, var("p.Ala152Thr")) increases sec(p(HGNC:MMP2)) View Subject | View Object

The level of secreted MMP-9 and MMP-2 was also increased in cortical neurons derived from a published iPSC line with the tau-A152T mutation (Fong et al., 2013) (Figures 2E and 2F) PubMed:27594586

g(DBSNP:rs63751011) causesNoChange a(GO:"symmetric, GABA-ergic, inhibitory synapse") View Subject | View Object

The percentages of VGLUT1-positive excitatory and GABA-positive inhibitory neurons were similar in neuronal cultures differentiated from control and patient iPSCs (Figures S2B and S2C) PubMed:27594586

p(HGNC:MAPT, var("p.Ala152Thr")) increases act(p(HGNC:MMP9)) View Subject | View Object

It is worth noting that the level and activity of secreted MMP-9 in tau- A152T neurons is also substantially higher than that in MAPT IVS10+16 neurons (Figure 2) PubMed:27594586

g(DBSNP:rs63751011) causesNoChange bp(GO:"neuron differentiation") View Subject | View Object

Thus, both molecular and electrophysiological analyses suggest MAPT mutations do not affect early neuronal differentiation PubMed:27594586

p(HGNC:MAPT, var("p.Ala152Thr")) causesNoChange p(HGNC:SLC17A7) View Subject | View Object

The percentages of VGLUT1-positive excitatory and GABA-positive inhibitory neurons were similar in neuronal cultures differentiated from control and patient iPSCs (Figures S2B and S2C) PubMed:27594586

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.