a(CHEBI:rolipram) increases a(CHEBI:"3',5'-cyclic AMP")

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PubMed:29626319

Impairment of 26S proteasome induced by tau can be prevented early in disease through activation of cAMP-PKA signaling, and raising the levels of cAMP with rolipram may enhance tau degradation (Myeku et al. 2016)

Related Edges 4

• a(CHEBI:"3',5'-cyclic AMP") increases deg(p(HGNC:MAPT))
• a(CHEBI:rolipram) increases deg(p(HGNC:MAPT))
• bp(GO:"cAMP-mediated signaling") increases p(HGNC:PSMD7)
• p(HGNC:MAPT) decreases p(HGNC:PSMD7)

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