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Entity

Name
3',5'-cyclic AMP
Namespace
chebi
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/chebi-names.belns

Appears in Networks 6

albuquerque2009 v1.0.0

This file encodes the article Mammalian Nicotinic Acetylcholine Receptors: From Structure to Function by Albuquerque et al, 2009

Activation of M1 and M4 muscarinic receptors as potential treatments for Alzheimer's disease and schizophrenia. v1.0.0

This file encodes the article Activation of M1 and M4 muscarinic receptors as potential treatments for Alzheimer’s disease and schizophrenia by Choi et al, 2014

M1 muscarinic acetylcholine receptor in Alzheimer’s disease v1.0.0

This file encodes the article M1 muscarinic acetylcholine receptor in Alzheimer’s disease by Jiang et al, 2014

In-Edges 9

act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) regulates a(CHEBI:"3',5'-cyclic AMP") View Subject | View Object

The metabotropic receptors are second messenger, G protein-coupled seven-transmembrane proteins. They are classically defined as being activated by muscarine, a toxin from the mushroom Amanita muscaria, and inhibited by atropine, a toxin from Atropa belladonna, a member of the nightshade family. Both toxins cross the blood-brain barrier poorly and were discovered primarily from their influences on postganglionic parasympathetic nervous system functions. Activation of muscarinic AChRs is relatively slow (milliseconds to seconds) and, depending on the subtypes present (M1- M5), they directly alter cellular homeostasis of phospholipase C, inositol trisphosphate, cAMP, and free calcium. PubMed:19126755

Appears in Networks:
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complex(p(HGNC:CHRM2), p(HGNC:GNAI1)) decreases a(CHEBI:"3',5'-cyclic AMP") View Subject | View Object

M1, M3, and M5 all signal primarily via the Galphaq G-protein and induce Ca2+ mobilization and inositol trisphosphate (IP3) production, while M2 and M4 signal via the Galphai G-protein to inhibit cyclic adenosine monophosphate (cAMP) production. PubMed:24511233

complex(p(HGNC:CHRM4), p(HGNC:GNAI1)) decreases a(CHEBI:"3',5'-cyclic AMP") View Subject | View Object

M1, M3, and M5 all signal primarily via the Galphaq G-protein and induce Ca2+ mobilization and inositol trisphosphate (IP3) production, while M2 and M4 signal via the Galphai G-protein to inhibit cyclic adenosine monophosphate (cAMP) production. PubMed:24511233

complex(p(HGNC:CHRM2), p(INTERPRO:"G-protein alpha subunit, group I")) decreases a(CHEBI:"3',5'-cyclic AMP") View Subject | View Object

Activation of Gαi coupled muscarinic receptors leads to inhibition of adenylyl cyclase and reduction of cyclic adenosine monophosphate (cAMP) levels, promoting inhibition of voltage-gated Ca2+ channels and, thus, diminishing cell excitability PubMed:26813123

complex(p(HGNC:CHRM4), p(INTERPRO:"G-protein alpha subunit, group I")) decreases a(CHEBI:"3',5'-cyclic AMP") View Subject | View Object

Activation of Gαi coupled muscarinic receptors leads to inhibition of adenylyl cyclase and reduction of cyclic adenosine monophosphate (cAMP) levels, promoting inhibition of voltage-gated Ca2+ channels and, thus, diminishing cell excitability PubMed:26813123

complex(p(HGNC:CHRM2), p(HGNC:GNAO1)) decreases a(CHEBI:"3',5'-cyclic AMP") View Subject | View Object

So far, five mAChR subtypes (M1– M5) have been identified and are divided into two categories based on the manner of signal transduction: M1, M3, and M5 subtypes preferentially interact with the Gq/11 family of G proteins, activating phospholipase C and mobilizing intracellular calcium, while M2 and M4 subtypes couple to the Go/i family, inhibiting adenylate cyclases and reducing intracellular cAMP levels PubMed:24590577

complex(p(HGNC:CHRM4), p(HGNC:GNAO1)) decreases a(CHEBI:"3',5'-cyclic AMP") View Subject | View Object

So far, five mAChR subtypes (M1– M5) have been identified and are divided into two categories based on the manner of signal transduction: M1, M3, and M5 subtypes preferentially interact with the Gq/11 family of G proteins, activating phospholipase C and mobilizing intracellular calcium, while M2 and M4 subtypes couple to the Go/i family, inhibiting adenylate cyclases and reducing intracellular cAMP levels PubMed:24590577

a(CHEBI:rolipram) increases a(CHEBI:"3',5'-cyclic AMP") View Subject | View Object

Impairment of 26S proteasome induced by tau can be prevented early in disease through activation of cAMP-PKA signaling, and raising the levels of cAMP with rolipram may enhance tau degradation (Myeku et al. 2016) PubMed:29626319

Out-Edges 1

a(CHEBI:"3',5'-cyclic AMP") increases deg(p(HGNC:MAPT)) View Subject | View Object

Impairment of 26S proteasome induced by tau can be prevented early in disease through activation of cAMP-PKA signaling, and raising the levels of cAMP with rolipram may enhance tau degradation (Myeku et al. 2016) PubMed:29626319

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.