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composite(a(CHEBI:"3',5'-cyclic AMP"), p(FPLX:PKC))

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Nicotinic acetylcholine receptor signalling: roles in Alzheimer's disease and amyloid neuroprotection. v1.0.0

In-Edges 0

Out-Edges 3

composite(a(CHEBI:"3',5'-cyclic AMP"), p(FPLX:PKC)) hasComponent a(CHEBI:"3',5'-cyclic AMP") View Subject | View Object

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composite(a(CHEBI:"3',5'-cyclic AMP"), p(FPLX:PKC)) hasComponent p(FPLX:PKC) View Subject | View Object

Appears in Networks:

composite(a(CHEBI:"3',5'-cyclic AMP"), p(FPLX:PKC)) regulates act(a(CHEBI:nicotine)) View Subject | View Object

The nicotine-induced nAChR up-regulation in human SH-EP1 cells heterologously expressing alpha7 nAChRs is mediated by cAMP and protein kinase C (PKC) (Nuutinen et al., 2006). The effects of long-term nicotine treatment on nAChR expression in rat brain differs for receptors of different subtype composition (most pronounced up-regulation being observed for alpha4beta2 receptors) and for different brain regions (Nguyen et al., 2003). PubMed:19293145

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About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.