a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") increases bp(GO:"excitatory postsynaptic potential")

PubMed:24511233

In brain slice electrophysiology studies, BQCA enhanced excitatory postsynaptic currents in medial prefrontal cortical neurons,69 an area critical for higher cognitive, learning, and memory functions.70 In pre-clinical animal studies, BQCA reversed scopolamine-impaired contextual fear conditioning and rescued medial prefrontal cortex-dependent discrimination reversal learning deficits in a transgenic mouse model of AD.

Related Edges 9

• a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") decreases act(a(CHEBI:scopolamine))
• a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") increases bp(GO:"behavioral fear response")
• a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") increases bp(GO:learning)
• a(MESH:"Prefrontal Cortex") association bp(GO:cognition)
• a(MESH:"Prefrontal Cortex") association bp(GO:learning)
• a(MESH:"Prefrontal Cortex") association bp(GO:memory)
• bp(GO:cognition) association a(MESH:"Prefrontal Cortex")
• bp(GO:learning) association a(MESH:"Prefrontal Cortex")
• bp(GO:memory) association a(MESH:"Prefrontal Cortex")

MeSH

Prefrontal Cortex

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