a(CHEBI:"kynurenic acid") decreases act(p(HGNC:CHRNA7))

PubMed:19126755

Chronic alpha7 nAChR inhibition in the hippocampus by elevated levels of KYNA can contribute to auditory gating deficits, which appear to be associated with the development of schizophrenia (156). It is also feasible that KYNAinduced inhibition of alpha7 nAChRs contributes to the cognitive impairment observed in patients with AD and schizophrenia (273).

Related Edges 8

• bp(GO:cognition) association act(p(HGNC:CHRNA7))
• bp(GO:cognition) negativeCorrelation path(MESH:"Alzheimer Disease")
• act(p(HGNC:CHRNA7)) association bp(GO:cognition)
• act(p(HGNC:CHRNA7)) association path(MESH:"Sensory Gating")
• path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:cognition)
• path(MESH:"Sensory Gating") association path(MESH:Schizophrenia)
• path(MESH:"Sensory Gating") association act(p(HGNC:CHRNA7))
• path(MESH:Schizophrenia) association path(MESH:"Sensory Gating")

MeSH

Hippocampus

Text Location

Review

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