p(HGNC:SERPINA1) decreases a(MESH:"Cell Adhesion Molecules")

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PubMed:28716864

Based on the previous findings that hemin induces neutrophil adhesion to endothelial cells [8] and that A1AT protects endothelial cells from neutrophil adhesion induced by fMLP [27], we investigated whether A1AT, as a scavenger of hemin, can prevent hemin-induced neutrophil adhesion to HUVECs. As shown in Fig. 4, neutrophils treated with hemin or fMLP (used as a positive control) exhibited a 3-fold higher adhesion to HUVECs compared with controls. However, the adherence of neutrophils treated with hemin/A1AT did not differ from controls (Fig. 4).

Related Edges 2

• a(CHEBI:heme) positiveCorrelation a(MESH:"Cell Adhesion Molecules")
• a(MESH:"Cell Adhesion Molecules") positiveCorrelation a(CHEBI:heme)

Cell Ontology (CL)

endothelial cell

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